darolutamide

Darolutamide (pronounced [DAR oh LOO ta mide]) is also known by the brand name, Nubeqa. It is a type of chemotherapy and an antineoplastic (anticancer) drug that belongs to a class called antiandrogens.

Improved survival at 4 years After 4 years, about 63% of patients who received darolutamide were still alive compared with about 50% of patients who received placebo.

You usually carry on taking darolutamide for as long as the treatment is working, and you are not experiencing too many side effects.

During long-term darolutamide therapy, few patients experienced TEAEs commonly associated with ARi therapy (fatigue, n = 3; falls, including accidents, n = 3; bone fractures, n = 2; hypertension, n = 2; rash, n = 1). Table 1 Treatment-emergent adverse events during long-term darolutamide treatment.

Nubeqa Prices, Coupons and Patient Assistance Programs. Nubeqa (darolutamide) is a member of the antiandrogens drug class and is commonly used for Prostate Cancer. The cost for Nubeqa oral tablet 300 mg is around $14,303 for a supply of 120 tablets, depending on the pharmacy you visit.

PROVEN RESULTS IN mHSPC. *NUBEQA combination=NUBEQA + hormone therapy with docetaxel (chemotherapy). 32% lower risk of dying than men who only received hormone therapy + chemotherapy.

According to a presentation at the2023 American Urological Association (AUA) Annual Meeting, undetectable PSA responses were significantly higher with darolutamide, at 48.7% and 57.1% at weeks 24 and 36, respectively, vs 23.9% and 25.1% with placebo.

Nubeqa has an average rating of 10.0 out of 10 from a total of 1 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. Zytiga has an average rating of 8.4 out of 10 from a total of 40 ratings on Drugs.com.

It is also used when the cancer has spread to other parts of the body but responds to treatment that lowers testosterone levels (hormone sensitive). It is used in combination with docetaxel (another cancer medicine) and a treatment called androgen deprivation therapy (treatment to lower male sex hormones).

NUBEQA HAS 100% COVERAGE ACROSS MEDICARE PART D PLANS NATIONWIDE. *Restrictions may apply. For full terms and conditions, please call Access Services by Bayer™ at 1-800-288-8374. Patients who are enrolled in any type of government insurance or reimbursement programs are not eligible.

ADT reduces testosterone levels in the blood. Testosterone is a hormone made mainly in the testes and is needed to develop and maintain male sex characteristics, such as facial hair, deep voice, and muscle growth. It also plays a role in prostate cancer development.

Alcohol: Nubeqa is not known to interact with alcohol. But alcohol and Nubeqa may cause some of the same side effects, such as nausea and fatigue (low energy). If you drink, combining this drug with alcohol may raise your risk of these side effects.

Check with your doctor as soon as possible if any of the following side effects occur: bone fractures. signs of heart problems (e.g., fast, irregular heartbeat or pulse, chest pain, sudden weight gain, difficulty breathing, leg swelling)

The overall survival at 4 years was 62.7% (95% CI, 58.7 to 66.7) in the darolutamide group and 50.4% (95% CI, 46.3 to 54.6) in the placebo group.

Women and children should not use this medicine. Darolutamide may also cause birth defects if the father is using it when his sexual partner becomes pregnant. You must use an effective method of birth control during treatment with this medicine and for 1 week after the last dose.

An oral treatment that is not chemotherapy NUBEQA is a prescription medication used to treat adults with prostate cancer: that has not spread to other parts of the body and no longer responds to medical or surgical treatment that lowers testosterone (non-metastatic castration-resistant prostate cancer, or nmCRPC)

Darolutamide (Oral Route)

These results suggest that darolutamide has optimal efficacy and safety profile among approved treatments and that abiraterone acetate, a less expensive alternative to approved treatments, may offer comparable value to patients with nmCRPC.

Life expectancy: The studies show that abiraterone acetate can prolong life. In the larger study, about 50 out of 100 men who had the standard treatment were still alive after 3 years, while after the same period of time 70 out of 100 men who had treatment with abiraterone acetate were still alive.

Comparing Nubeqa vs Xtandi Nubeqa has an average rating of 10.0 out of 10 from a total of 1 ratings on Drugs.com. 100% of reviewers reported a positive effect, while 0% reported a negative effect. Xtandi has an average rating of 5.4 out of 10 from a total of 20 ratings on Drugs.com.

medwireNews: The EMA has recommended that the indication for darolutamide be expanded to include the treatment of metastatic hormone-sensitive prostate cancer (HSPC).

Remember that this medication has been prescribed because your doctor has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. This medication may raise your blood pressure.

Darolutamide is in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of cancer cells.

Overall 3.9% of patients receiving NUBEQA and 3.2% of patients receiving placebo died from adverse reactions, which included death (0.4%), cardiac failure (0.3%), cardiac arrest (0.2%), general physical health deterioration (0.2%), and pulmonary embolism (0.2%) for NUBEQA.