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Daliresp is the brand name for roflumilast and is available as an oral tablet.

Daliresp is available as a 250 mcg and 500 mcg oral tablet.

Daliresp is a PDE-4 inhibitor used for COPD (chronic obstructive pulmonary disease).

Daliresp is a phosphodiesterase-4 (PDE-4) inhibitor. PDE-4 is a protein in your body that is involved in making inflammatory chemicals in the lungs. Because it blocks PDE-4, Daliresp prevents inflammation, which helps you breathe better and prevent COPD flare-ups.

Daliresp is typically taken by mouth once daily with or without food. The typical maintenance dose is 500 mcg per day.

Daliresp is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have moderate to severe liver impairment.

Common side effects of Daliresp include:

• Diarrhea (10%)
• Weight loss (8%)
• Nausea (5%)
• Headache (4%)

Other Side Effects:

• Back pain
• Flu
• Difficulty sleeping
• Dizziness
• Loss of appetite
• Upset stomach
• Runny nose
• Sinus inflammation
• Urinary tract infection
• Muscle spasm
• Tremor
• Anxiety
• Depression

Serious side effects are rare with Daliresp. Contact your healthcare provider immediately if you experience any of the following.

• Depression or suicidal thoughts

The following medications may interact with Daliresp:

• Inhibitors of CYP3A4 or dual inhibitors of CYP3A4 and CYP1A2 (e.g., erythromycin, ketoconazole, fluvoxamine, enoxacin, cimetidine) – Will increase Daliresp levels and may result in increased adverse reactions

AstraZeneca

It is not known if Daliresp will harm your unborn baby. If you become pregnant while receiving Daliresp, talk to your healthcare provider.

• Roflumilast