Used for Heart Failure

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Manufactured by Amgen Inc.

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CORLANOR Uses, Side Effects, Interactions, Warnings & Dosing



CORLANOR is the brand name for ivabradine oral tablet and solution.

What dosages is CORLANOR available in?

What dosages is CORLANOR available in?

CORLANOR is available as a 5 mg and 7.5 mg oral tablet and a 5 mg/mL oral solution.

What is CORLANOR used for?

What is CORLANOR used for?

CORLANOR is a hyperpolarization-activated cyclic nucleotide-gated channel blocker that is used:
To lower the risk of hospitalization for worsening heart failure in adults
To treat heart failure due to an enlarged heart (dilated cardiomyopathy) in children ages 6 months and older

How does CORLANOR work?

How does CORLANOR work?

CORLANOR is a hyperpolarization-activated cyclic nucleotide-gated channel blocker, or HCN channel blocker for short. It works by blocking specific channels within your heart to slow the electrical activity in your heart. As a result, your heart rate slows down. This can help put less stress on the heart in people with heart failure.

How do I take CORLANOR?

How do I take CORLANOR?

CORLANOR is dosed as follows:
Adults: The typical starting dose is 5 mg by mouth twice a day with food. The dose can be raised to a maximum of 7.5 mg twice a day if needed.

Children ages 6 months and older weighing more than 88 pounds (40 kg): The typical starting dose is 2.5 mg by mouth twice a day with food. The dose can be raised to a maximum of 7.5 mg twice a day if needed.

Children ages 6 months and older weighing less than 88 pounds (40 kg): The typical dose is 0.05 mg/kg of body weight by mouth twice a day with food. The maximum dose varies since it’s based on your child’s age and weight, but should never be more than 7.5 mg twice a day. The provider will help calculate the right dose for you to give to your child.

Is it safe for me to take CORLANOR?

Is it safe for me to take CORLANOR?

CORLANOR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
Acute decompensated heart failure.
Clinically significant hypotension.
Sick sinus syndrome, sinoatrial block or 3rd degree AV block, unless a functioning demand pacemaker is present.
Clinically significant bradycardia.
Severe hepatic impairment.
Heart rate maintained exclusively by the pacemaker .
In combination with strong cytochrome CYP3A4 inhibitors.

CORLANOR Common Side Effects

CORLANOR Common Side Effects

Common side effects of CORLANOR:

  • Slowed heart rate
  • High blood pressure or a rise in blood pressure
  • Abnormal heart rhythm called atrial fibrillation
CORLANOR Serious Side Effects

CORLANOR Serious Side Effects

Serious side effects are rare with CORLANOR. Contact your healthcare provider immediately if you experience any of the following.

Irregular heart rhythm: a racing or pounding heart, chest pressure or pain, shortness of breath, dizziness, fainting
Slow heart rate: dizziness, a tired feeling, unexplainable lack of energy; poor feeding, trouble breathing, or turning blue in children

Effects of other drugs, drug classes and over-the-counter products on CORLANOR

Effects of other drugs, drug classes and over-the-counter products on CORLANOR

The following medications may interact with CORLANOR:

  • Avoid CYP3A4 inhibitors or inducers.
  • Negative chronotropes increase risk of bradycardia; monitor heart rate.
Who makes CORLANOR?

Who makes CORLANOR?

Amgen Inc.

Is CORLANOR safe in pregnancy?

Is CORLANOR safe in pregnancy?

CORLANOR may cause harm to your unborn baby. Females who are able to get pregnant:
Must use effective birth control during treatment with CORLANOR.
Tell your doctor right away if you become pregnant during treatment with CORLANOR.


What to do if you missed your CORLANOR dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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