Used for Glaucoma

View COMBIGAN savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or COMBIGAN Patient Assistance Program.

Programs are suitable for individuals who want to buy COMBIGAN without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Allergan

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about COMBIGAN



COMBIGAN is the brand name for brimonidine/timolol and is available as an ophthalmic solution.

What dosages is COMBIGAN available in?

What dosages is COMBIGAN available in?

COMBIGAN is available as an ophthalmic solution that contains 0.2% brimonidine and 0.5% timolol.

What is COMBIGAN used for?

What is COMBIGAN used for?

  • COMBIGAN is an alpha agonist / beta blocker and is used to treat high pressure in the eye caused by glaucoma or ocular hypertension (high pressure inside the eye)
How does COMBIGAN work?

How does COMBIGAN work?

COMBIGAN is a combination of two medications. Brimonidine is an alpha agonist. It works to lower the production of fluids within the eye and help the flow of fluids out of the eye. Timolol is a beta blocker. It blocks beta receptors in the eye to lower eye pressure by lowering the amount of fluid in the eye.

How do I take COMBIGAN?

How do I take COMBIGAN?

  • COMBIGAN is typically dosed at 1 drop into the affected eye(s) twice a day (about 12 hours apart)
Is it safe for me to take COMBIGAN?

Is it safe for me to take COMBIGAN?

COMBIGAN is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:

  • Bronchial asthma, a history of bronchial asthma, severe chronic obstructive, pulmonary disease
  • Sinus bradycardia, atrioventricular block, overt cardiac failure, cardiogenic shock
  • Neonates and infants (under the age of 2 years)
  • Hypersensitivity to any component of this product
COMBIGAN Common Side Effects

COMBIGAN Common Side Effects

Common side effects of COMBIGAN:

  • Itching of the eyes
  • Burning and stinging of the eyes
  • Allergic inflammation (swelling) of the eye
COMBIGAN Serious Side Effects

COMBIGAN Serious Side Effects

Serious side effects are rare with COMBIGAN. Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reaction
  • Shortness of breath
  • Chest pain
  • Abnormal heartbeat
Effects of other drugs, drug classes and over-the-counter products on COMBIGAN

Effects of other drugs, drug classes and over-the-counter products on COMBIGAN

The following medications may interact with COMBIGAN:

  • Antihypertensives/cardiac glycosides may lower blood pressure
  • Concomitant use with systemic beta-blockers may potentiate systemic beta-blockade
  • Oral or intravenous calcium antagonists may cause atrioventricular conduction disturbances, left ventricular failure, and hypotension
  • Catecholamine-depleting drugs may have additive effects and produce hypotension and/or marked bradycardia
  • Use with CNS depressants may result in an additive or potentiating effect
  • Digitalis and calcium antagonists may have additive effects in prolonging atrioventricular conduction time
  • CYP2D6 inhibitors may potentiate systemic beta-blockade
  • Tricyclic antidepressants may potentially blunt the hypotensive effect of systemic clonidine
  • Monoamine oxidase inhibitors may result in increased hypotension
Who makes COMBIGAN?

Who makes COMBIGAN?


Is COMBIGAN safe in pregnancy?

Is COMBIGAN safe in pregnancy?

There are no adequate and well-controlled studies in pregnant women; however, in animal studies, brimonidine
crossed the placenta and entered into the fetal circulation to a limited extent. Because animal reproduction studies are not always predictive of human response, COMBIGAN should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.


What to do if you missed your COMBIGAN dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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