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Brimonidine Tartrate/Timolol Maleate is available as an ophthalmic solution that contains 0.2% brimonidine and 0.5% timolol.

• Brimonidine Tartrate/Timolol Maleate is an alpha agonist / beta blocker and is used to treat high pressure in the eye caused by glaucoma or ocular hypertension (high pressure inside the eye)

Brimonidine Tartrate/Timolol Maleate is a combination of two medications. Brimonidine is an alpha agonist. It works to lower the production of fluids within the eye and help the flow of fluids out of the eye. Timolol is a beta blocker. It blocks beta receptors in the eye to lower eye pressure by lowering the amount of fluid in the eye.

• Brimonidine Tartrate/Timolol Maleate is typically dosed at 1 drop into the affected eye(s) twice a day (about 12 hours apart)

Brimonidine Tartrate/Timolol Maleate is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have any of the following:

• Bronchial asthma, a history of bronchial asthma, severe chronic obstructive, pulmonary disease
• Sinus bradycardia, atrioventricular block, overt cardiac failure, cardiogenic shock
• Neonates and infants (under the age of 2 years)
• Hypersensitivity to any component of this product

Common side effects of Brimonidine Tartrate/Timolol Maleate:

• Itching of the eyes
• Burning and stinging of the eyes
• Allergic inflammation (swelling) of the eye

Serious side effects are rare with Brimonidine Tartrate/Timolol Maleate. Contact your healthcare provider immediately if you experience any of the following.

• Allergic reaction
• Shortness of breath
• Chest pain
• Abnormal heartbeat

The following medications may interact with Brimonidine Tartrate/Timolol Maleate:

• Antihypertensives/cardiac glycosides may lower blood pressure
• Concomitant use with systemic beta-blockers may potentiate systemic beta-blockade
• Oral or intravenous calcium antagonists may cause atrioventricular conduction disturbances, left ventricular failure, and hypotension
• Catecholamine-depleting drugs may have additive effects and produce hypotension and/or marked bradycardia
• Use with CNS depressants may result in an additive or potentiating effect
• Digitalis and calcium antagonists may have additive effects in prolonging atrioventricular conduction time
• CYP2D6 inhibitors may potentiate systemic beta-blockade
• Tricyclic antidepressants may potentially blunt the hypotensive effect of systemic clonidine
• Monoamine oxidase inhibitors may result in increased hypotension

Various FDA-approved generic manufacturers

There are no adequate and well-controlled studies in pregnant women; however, in animal studies, brimonidine
crossed the placenta and entered into the fetal circulation to a limited extent. Because animal reproduction studies are not always predictive of human response, Brimonidine Tartrate/Timolol Maleate should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.

• Combigan