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Manufactured by various FDA-approved generic manufacturers.

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cinacalcet Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is cinacalcet available in?

What dosages is cinacalcet available in?

cinacalcet is available as a 30 mg, 60 mg, and 90 mg oral tablet.

What is cinacalcet used for?

What is cinacalcet used for?

cinacalcet is a calcimimetic that is used to treat high calcium levels from:

  • Overactive parathyroid that can’t be removed by surgery
  • Overactive parathyroid in people with chronic kidney disease (CKD) who are on dialysis
  • Parathyroid cancer
How does cinacalcet work?

How does cinacalcet work?

cinacalcet is in a drug class called calcimimetics. It works on your parathyroid glands to lower the amount of parathyroid hormone they produce. In doing so, it lowers the amount of calcium and phosphorus in your body.

How do I take cinacalcet?

How do I take cinacalcet?

For overactive parathyroid in CKD: The typical starting dose is 30 mg by mouth once daily with food or after a meal. Your provider will adjust the dose based on your parathyroid hormone levels, as well as blood calcium and phosphorus levels. The maximum dose is 180 mg once daily. For overactive parathyroid and parathyroid cancer: The typical starting dose is 30 mg by mouth twice daily with food or after a meal. Your provider will adjust the dose based on your blood calcium levels. The maximum dose is 90 mg three to four times daily.

Is it safe for me to take cinacalcet?

Is it safe for me to take cinacalcet?

cinacalcet is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if your serum calcium is less than
the lower limit of the normal range.

cinacalcet Common Side Effects

cinacalcet Common Side Effects

Common side effects of cinacalcet:

  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach pain
  • Muscle aches
  • Dizziness
cinacalcet Serious Side Effects

cinacalcet Serious Side Effects

Serious side effects are rare with cinacalcet. Contact your healthcare provider immediately if you experience any of the following.

  • Very low levels of calcium: muscle pain and spasms, pins and needles sensation, seizures
  • Stomach bleed: vomiting that won’t stop, blood in your vomit or stool, black, tarry stools, really bad stomach pain
  • Heart problems: abnormal heartbeats, trouble breathing, sudden weight gain or swelling of your arms and legs, feeling confused
Effects of other drugs, drug classes and over-the-counter products on cinacalcet

Effects of other drugs, drug classes and over-the-counter products on cinacalcet

The following medications may interact with cinacalcet:

  • Co-administration with a strong CYP3A4 inhibitor may increase serum levels of cinacalcet. Dose adjustment and monitoring of iPTH serum phosphorus and serum calcium may be required
  • Cinacalcet is a strong inhibitor of CYP2D6. Dose adjustments may be required for concomitant medications that are predominantly metabolized by CYP2D6
Who makes cinacalcet?

Who makes cinacalcet?

Various FDA-approved generic manufacturers

Is cinacalcet safe in pregnancy?

Is cinacalcet safe in pregnancy?

It is not known if cinacalcet will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.


What to do if you missed your cinacalcet dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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