Chlorthalidone Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Chlorthalidone
    Generic for Hygroton
    30 tablets $6.6 USD
    Save $27.60
  3. Chlorthalidone
    Generic for Hygroton
    15 tablets $4.5 USD
    Save $12.60
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Do you need a prescription for chlorthalidone?

Yes, chlorthalidone is only available with a valid physician Rx.

How much is chlorthalidone without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase chlorthalidone, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for chlorthalidone in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a chlorthalidone savings card?

Yes. Save up to 90% on your chlorthalidone with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a chlorthalidone coupon provider in the US?

No. Now Patient does not provide chlorthalidone coupons or FREE chlorthalidone samples.

Do you accept commercial, Medicare or Medicaid coverage for chlorthalidone in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much chlorthalidone?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using chlorthalidone. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much chlorthalidone. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

FDA approval of chlorthalidone

Chlorthalidone has been approved by the U.S. Food and Drug Administration (FDA) for the treatment of high blood pressure and edema (fluid retention).

US brand name of chlorthalidone

Chlorthalidone is available under various brand names, including Thalitone and Hygroton. These brands are manufactured by different pharmaceutical companies.

UK brand name of chlorthalidone

In the UK, chlorthalidone is available under the brand name Hygroton. Hygroton is manufactured by Sanofi.

Availability of chlorthalidone

Chlorthalidone is available as a prescription medication and is not available over-the-counter (OTC).

NHS prescription (UK) for chlorthalidone

Chlorthalidone is available in the UK with an NHS prescription.

Conditions treated by chlorthalidone

Chlorthalidone is a thiazide-like diuretic, used for the treatment of hypertension (high blood pressure). This helps to prevent strokes, cardiovascular disease, heart attacks, and other renal problems. Chlorthalidone is also used to reduce salt and water content caused by heart failure, liver disease, and kidney disease.

Mechanism of action

Chlorthalidone belongs to the class of drugs known as thiazide diuretics. It works by increasing the excretion of water and salt through the kidneys, leading to a reduction in fluid volume and a decrease in blood pressure.

Warnings and precautions for chlorthalidone

  • If you have had an allergic reaction to chlorthalidone or other sulfonamide-derived medications, inform your healthcare provider
  • Chlorthalidone may cause electrolyte imbalances, such as low potassium levels (hypokalemia) or low sodium levels (hyponatremia). Tell your doctor if you have chronic kidney disease, or liver disease
  • Chlorthalidone may affect blood sugar levels. Monitor your blood sugar closely if you have diabetes
  • Chlorthalidone may increase uric acid levels, potentially triggering gout attacks in susceptible individuals

Side effects of chlorthalidone

  • Increased urination
  • Lightheadedness, dizziness
  • Fatigue
  • Constipation
  • Muscle cramps
  • Upset stomach
  • Pancreatitis

Serious side effects such as allergic reactions are rare. Get medical help right away if you develop a rash, swelling of the face, tongue, or throat), dizziness, or have trouble breathing.

Dosage of chlorthalidone

The dosage of chlorthalidone may vary depending on the condition being treated and individual patient factors. It is important to follow the instructions provided by your healthcare provider.

Interactions with other drugs

Chlorthalidone may interact with other medications, including nonsteroidal anti-inflammatory drugs (such as ibuprofen and naproxen), lithium, and certain blood pressure medications. It is important to inform your healthcare provider about all the prescription drugs, over the counter medication, multivitamins, and supplements you are taking, to avoid potential drug interactions and adverse effects.

Use in pregnancy

Consult your healthcare provider before using chlorthalidone if you are pregnant or planning to become pregnant. The potential risks and benefits should be considered.

Use in breastfeeding

Chlorthalidone may pass into breast milk and could have adverse effects on the nursing infant. Consult your healthcare provider before using chlorthalidone while breastfeeding.

Similar drugs to chlorthalidone

Similar antihypertensive drugs for the treatment of high blood pressure includes, beta-blockers, angiotensin-converting enzyme (ACE) inhibitors, and calcium channel blockers.



Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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