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MEDICAL INFORMATION
Chlorthalidone Key Facts
What dosages is Chlorthalidone available in?
Chlorthalidone is available as a 25 mg and 50 mg oral tablet.
What is Chlorthalidone used for?
Chlorthalidone is a diuretic (water pill) and is used to treat hypertension (high blood pressure), and swelling from fluids (edema) caused by heart failure, kidney problems, liver problems, or corticosteroid and estrogen therapy.
How does Chlorthalidone work?
Chlorthalidone is a thiazide-like diuretic (water pill) that makes you urinate more. It works in the kidneys to remove extra water and certain electrolytes, while lowering blood pressure and getting rid of swelling.
How do I take Chlorthalidone?
Chlorthalidone is typically dosed as 25 mg by mouth once daily for hypertension. If needed, your physician will adjust your dose. The maximum dose is 100 mg once daily. For swelling, the typical starting dose is 50 mg to 100 mg by mouth once daily. If needed, your provider will adjust your dose. The maximum dose is 200 mg once daily.
Is it safe for me to take Chlorthalidone?
Chlorthalidone is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have anuria.
Chlorthalidone Common Side Effects
Common side effects of Chlorthalidone include:
- Urinating more
- Dizziness
- Headache
- Sensitivity to the sun
Chlorthalidone Serious Side Effects
Serious side effects are rare with Chlorthalidone. Contact your healthcare provider immediately if you experience any of the following:
- Allergic reaction (difficulty breathing, swelling of the tongue/mouth/throat, rash or hives).
- Kidney problems (not urinating as often as you usually do, feeling tired, confusion).
- Severe liver issues (yellowing of the eyes or skin, pale stool, dark urine, confusion).
- Electrolyte levels out of balance (muscle weakness, muscle twitching, tiredness, confusion, seizures).
Effects of other drugs, drug classes and over-the-counter products on Chlorthalidone
The following medications may interact with Chlorthalidone:
- Antihypertensive drugs – Chlorthalidone may add to or potentiate the action of other antihypertensive drugs
- Lithium – Lithium renal clearance is reduced by Chlorthalidone, increasing the risk of lithium toxicity
Who makes Chlorthalidone?
Various FDA-approved generic manufacturers
Is Chlorthalidone safe in pregnancy?
Chlorthalidone may cause harm to your unborn baby and should not be used as first-line therapy to treat hypertension in pregnant women.
What is the brand name for Chlorthalidone?
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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We are a broad skilled and passionate group of clinicians with experience of operating in health systems in the United Kingdom & United States. Providing excellent care and advice is at the heart of everything we do. You can read more about our medical team by visiting the medical team page or learn more about how we curate content by visiting our editorial process
Daniel Cheung
Pharmacist Independent Prescriber, Pharmacist
Ihtesham Sabri
Medical Director
Stefano Mirabello
Pharmacist Independent Prescriber, Clinical Safety Officer (CSO), Pharmacist
Jamie Winn
US Board Certified Pharmacist
DeLon Canterbury
US Board Certified Pharmacist/PGX & Deprescribing Specialist
Rajive Patel
Medical Writer
Navin Khosla
UK Responsible Person (UKRP), Pharmacist Independent Prescriber, Clinical Safety Officer (CSO), Pharmacist
Monica Khosla
Medical Writer
Amish Patel
Pharmacist Independent Prescriber, Superintendant Pharmacist, Pharmacist
Aseel Hamoud Bedan
Hospital Consultant
Ketan Patel
Pharmacist Independent Prescriber, Pharmacist