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Bumetanide is available as a 0.5 mg, 1 mg, and 2 mg oral tablet.

Bumetanide is a diuretic (water pill) used for swelling (edema) due to congestive heart failure, liver problems, or kidney problems.

Bumetanide is a loop diuretic (water pill) that makes you urinate more. It works in the kidneys to get rid of extra water and electrolytes (like sodium and potassium), which helps ease swelling.

Bumetanide is typically taken by mouth once daily. Depending on your condition, your provider might ask you to take it every other day or every 2 days.

Bumetanide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you have anuria, hepatic coma or in states of severe electrolyte depletion until the condition is improved or corrected.

Common side effects of Bumetanide include:

• Changes in electrolyte levels
• Muscle cramps
• Dizziness
• Headache
• Nausea

Serious side effects are rare with Bumetanide. Contact your healthcare provider immediately if you experience any of the following.

• Severe dehydration: feeling thirsty, lightheadedness, dry mouth, dark colored urine, urinating less
• Low levels of potassium in the blood: muscle weakness and spasms, tiredness, heart racing, constipation, tingling or numbness, nausea, vomiting, muscle pain, confusion
• Stevens-Johnson Syndrome and toxic epidermal necrolysis: skin pain, fever, body aches, red rash, peeling skin, blisters, sores

The following medications may interact with Bumetanide:

• Drugs With Nephrotoxic Potential – There has been no experience with the concurrent use of Bumetanide with drugs known to have a nephrotoxic potential. Therefore, the simultaneous administration of these drugs should be avoided
• Lithium – Lithium should generally not be given with diuretics because they reduce its renal clearance and add a high risk of lithium toxicity
• Probenecid – Pretreatment with probenecid reduces both the natriuresis and hyperreninemia produced by Bumetanide. Thus, probenecid should not be administered concurrently with Bumetanide
• Indomethacin – Indomethacin blunts increases in urine volume and sodium excretion so concurrent therapy with Bumetanide is thus not recommended

Antihypertensives: Bumetanide may potentiate the effect of various antihypertensive drugs, necessitating a reduction in the dosage of these drugs.

Various FDA-approved generic manufacturers

It is not known if Bumetanide will harm your unborn baby. If you become pregnant while receiving Bumetanide, talk to your healthcare provider.

• Bumex