alpelisib
Used for Cancer
Are you tired of high medication costs? Our service offers unbeatable savings on your alpelisib prescription medication. We provide a range of solutions to help you save up to 100% on your medication costs*. Whether you are insured, uninsured, underinsured, or simply looking to reduce your out-of-pocket expenses, we've got you covered.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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alpelisib key facts
What dosages is alpelisib available in?
alpelisib is available as a 50 mg, 125 mg, and 200 mg oral tablet.
What is alpelisib used for?
alpelisib is a kinase inhibitor that is used to treat PIK3CA-related overgrowth spectrum (PROS).
How does alpelisib work?
alpelisib is a kinase inhibitor. It works by preventing PI3K (a protein that signals your cells to grow) from working properly. People with PROS have abnormal PI3K proteins that cause uncontrollable cell growth, which lead to complications of the condition. By blocking PI3K from working properly, it helps stop your cells from growing too quickly.
How do I take alpelisib?
alpelisib is dosed as follows:
- Adults 18 years of age and older: The typical dose is 250 mg by mouth once per day
- Children ages 2 to 18 years old: The typical starting dose is 50 mg by mouth once per day. If your child is at least 6 years old and isn’t responding well to the medication, your child’s provider might raise the dose to 125 mg once per day
Is it safe for me to take alpelisib?
alpelisib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
alpelisib Common Side Effects
Common side effects of alpelisib:
- Diarrhea
- Inflammation and sores in mouth
- High blood sugar
- Eczema
- Dry skin
- Hair loss
alpelisib Serious Side Effects
Serious side effects are rare with alpelisib. Contact your healthcare provider immediately if you experience any of the following.
- Severe allergic reaction: hives; swelling of the lips, tongue, or face; difficulty breathing
- Severe skin reactions: red or purple skin rash, blisters on skin, peeling skin, fever
- Dangerously high blood sugar: frequently thirsty, needing to urinate often, difficulty breathing, rapid heartbeat, fruity breath, dry mouth, confusion
- Lung inflammation: cough, shortness of breath, chest pain
- Dehydration: dry mouth, not urinating as much, lightheadedness, dizziness
Effects of other drugs, drug classes and over-the-counter products on alpelisib
The following medications may interact with alpelisib:
- CYP3A4 Inducers: Avoid coadministration of alpelisib with a strong CYP3A4 inducer
- Breast Cancer Resistance Protein (BCRP) Inhibitors: Avoid the use of BCRP inhibitors in patients treated with alpelisib. If unable to use alternative drugs, closely monitor for increased adverse reactions.
- CYP2C9 Substrates: Closely monitor when alpelisib is coadministered with CYP2C9 substrates where decreases in the plasma concentration of these drugs may reduce activity
Who makes alpelisib?
Various FDA-approved generic manufacturers
Is alpelisib safe in pregnancy?
alpelisib can harm your unborn baby.
Females who are able to become pregnant:
- Your healthcare provider will check to see if you are pregnant before you start treatment with alpelisib
- You should use effective birth control during treatment with alpelisib and for 1 week after the last dose. Talk to
your healthcare provider about birth control methods that may be right for you during this time - If you become pregnant or think you are pregnant, tell your healthcare provider right away
- Males with female partners who are able to become pregnant should use condoms and effective birth control during treatment with alpelisib and for 1 week after the last dose. If your female partner becomes pregnant, tell your healthcare provider right away
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my alpelisib prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your alpelisib prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient alpelisib savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient alpelisib savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for alpelisib | Canadian Prescription Savings* for alpelisib | alpelisib Drug Coupon* | alpelisib Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of alpelisib?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for alpelisib | Canadian Prescription Savings* for alpelisib | alpelisib Drug Coupon* | alpelisib Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the alpelisib savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the alpelisib drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for alpelisib, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the alpelisib prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, alpelisib is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed alpelisib for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the alpelisib prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the alpelisib prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for alpelisib
If you are having trouble paying for your alpelisib medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for alpelisib you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- alpelisib is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers alpelisib
- If alpelisib is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for alpelisib
If you are having trouble paying for your alpelisib medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for alpelisib you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers alpelisib
- If alpelisib is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for alpelisib
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your alpelisib treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for alpelisib you will need to meet the following criteria:
- You must be currently insured and have coverage for alpelisib
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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Our head of US services is Dr. Jamie Winn.
You can lower the cost of your prescription medications using our various savings programs which include drug coupons, savings card and manufacturer-sponsored patient assistance programs.
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