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Alemtuzumab is available as a 12 mg/1.2 mL (10 mg/mL) single-use vial.

Alemtuzumab is an anti-CD52 monoclonal antibody that is used to treat relapsing forms of multiple sclerosis (MS) in adults who haven’t responded well enough to at least two other MS medications.

Alemtuzumab is a CD52 monoclonal antibody. The exact way it treats MS isn’t well-understood. But it’s thought to dampen the immune system by attaching to a protein called CD52 found on certain immune cells. This temporarily lowers the amount of immune cells in the body, which can lessen inflammation and bring relief of MS symptoms.

A full treatment with Alemtuzumab includes 2 treatment courses, given a year apart.

First treatment course: The typical dose is 12 mg infused into the veins (IV) once daily for 5 days by a healthcare provider.

Second treatment course: The second treatment course is given 1 year after the first treatment course. The typical dose is 12 mg infused IV once daily for 3 days by a healthcare provider.

If needed, your provider might have you continue with additional treatment courses of Alemtuzumab. Each additional course can be given 1 year after your last course. The typical dose is 12 mg infused IV once daily for 3 days.

Alemtuzumab is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have HIV.

• Common side effects of Alemtuzumab:
• Rash
• Headache
• Fever
• Sore throat, runny nose
• Nausea
• Urinary tract infection
• Tiredness
• Difficulty sleeping
• Upper respiratory tract infection
• Herpes viral infection
• Hives

Serious side effects are rare with Alemtuzumab. Contact your healthcare provider immediately if you experience any of the following.

Autoimmune problems: see the risks and warnings section for more specific autoimmune problems and their associated signs and symptoms
Serious allergic and infusion reactions: low or high blood pressure, chest pain, low or high heart rate, headache, fever, rash, nausea, hives, difficulty sleeping, chills, flushing, fatigue, shortness of breath, dizziness
Stroke: sudden trouble speaking, droopy face, sudden confusion, numbness or weakness in the face, arm, or leg
Cancers: new lumps or swelling in your neck, pain in the front of the neck, changes in your voice, trouble swallowing or breathing, constant cough not due to an infection, changes in your skin
Inflammatory problems: see the risks and warnings section for more specific inflammatory problems and their associated signs and symptoms
Serious infections: fever, difficulty breathing, diarrhea, weakness, cough, stomach pain, sweating, chills, burning when you urinate, urinating more often

• There are no major drug interactions listed for Alemtuzumab. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Various FDA-approved generic manufacturers

Alemtuzumab may harm your unborn
baby. You should use birth control while receiving Alemtuzumab and for 4 months
after your course of treatment.

• Lemtrada