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MEDICAL INFORMATION
Abrocitinib Key Facts
What dosages is Abrocitinib available in?
Abrocitinib is available as a 50 mg, 100 mg, and 200 mg oral tablet.
What is Abrocitinib used for?
Abrocitinib is a JAK inhibitor and is used to treat moderate-to-severe atopic dermatitis (eczema) in people age 12 years and older who didn’t respond to other treatments.
How does Abrocitinib work?
Abrocitinib is a janus kinase (JAK) inhibitor. It blocks an enzyme (protein) called JAK in the body that plays a role in inflammation. By stopping this enzyme from working, Abrocitinib lowers inflammation to relieve symptoms of atopic dermatitis.
How do I take Abrocitinib?
Abrocitinib is typically started at 100 mg by mouth once a day. Your provider might raise your dose to 200 mg once a day if your skin symptoms haven’t improved after 3 months. Your dose might differ if you have kidney problems, if you’re taking a medication that interacts with Abrocitinib, if your body breaks down Abrocitinib poorly based on genetic testing, or if you’re having side effects.
Is it safe for me to take Abrocitinib?
Abrocitinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. Antiplatelet therapies except for low-dose aspirin (≤81 mg daily), during the
first 3 months of treatment.
Abrocitinib Common Side Effects
Common side effects of Abrocitinib:
- Nausea
- Common cold
- Headache
- Acne
Abrocitinib Serious Side Effects
Serious side effects are rare with Abrocitinib. Contact your healthcare provider immediately if you experience any of the following.
- Stroke: sudden weakness in your body, trouble speaking, confusion, dizziness
- Arterial thrombosis (blood clot in the heart): chest pain; short of breath; pain in the jaw, neck, or back; feeling weak or light-headed
- Pulmonary embolism (blood clot in the lung): cough, chest pain, trouble breathing, racing heart
- Deep vein thrombosis (blood clot in the leg): leg cramp, swelling, pain, muscle tightness
- Serious bleeds: bleed or bruise easily, bleeding that’s hard to stop, coughing blood, stomach pain, blood in urine or stool
- Serious infections: fever, difficulty breathing, diarrhea, weakness, cough, stomach pain, sweating, chills, burning when you urinate, urinating more often
Effects of other drugs, drug classes and over-the-counter products on Abrocitinib
The following medications may interact with Abrocitinib:
- Strong inhibitors of CYP2C19: The recommended dose is 50 mg daily or 100 mg once daily for those patients who are not responding to 50 mg once daily
- Moderate to strong inhibitors of both CYP2C19 and CYP2C9, or strong
- CYP2C19 or CYP2C9 inducers: Avoid concomitant use.
- P-gp substrate where small concentration changes may lead to serious or life-threatening toxicities: Monitor or titrate dosage of P-gp substrate
Who makes Abrocitinib?
Various FDA-approved generic manufacturers
Is Abrocitinib safe in pregnancy?
It is not known if Abrocitinib will harm your unborn baby. Pfizer has a registry for women who take Abrocitinib during pregnancy. The purpose of this registry is to check the health of you and your baby. If you are pregnant or become pregnant during
treatment with Abrocitinib, talk to your healthcare provider about how you can join this pregnancy registry, or you may contact the registry at 1-877-311-3770 or The Abrocitinib Pregnancy Registry
.
What is the brand name for Abrocitinib?
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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