ZESTORETIC
Used for Hypertension, Heart Failure and Heart Attack
NowPatient helps you obtain your ZESTORETIC prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by AstraZeneca
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ZESTORETIC key facts
What is ZESTORETIC?
ZESTORETIC is the brand name for lisinopril/hydrochlorothiazide and is available as an oral tablet.
What dosages is ZESTORETIC available in?
ZESTORETIC contains lisinopril/hydrochlorothiazide and is a available as 10 mg/12. 5 mg, 20 mg/12.5 mg, and 20 mg/25 mg 30 mg oral tablet.
What is ZESTORETIC used for?
ZESTORETIC is an ACE inhibitor/thiazide diurectic that is used to treat high blood pressure.
How does ZESTORETIC work?
ZESTORETIC is a combination of two medications that work together to lower blood pressure. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. It relaxes your blood vessels by blocking a protein (ACE) that normally squeezes your blood vessels. Hydrochlorothiazide is a thiazide diuretic (water pill). It works in your kidneys to remove extra water and certain electrolytes (like sodium and potassium). This helps lower blood pressure.
How do I take ZESTORETIC?
ZESTORETIC is typically started at 10 mg/12.5 mg (lisinopril/hydrochlorothiazide) by mouth once daily. Your provider will adjust your dose based on how well it’s helping your blood pressure and if you’re having side effects. The maximum dose is 80 mg/50 mg (lisinopril/hydrochlorothiazide) once daily.
Is it safe for me to take ZESTORETIC?
ZESTORETIC is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
You should not use this medication if you are hypersensitive to this product and have a history of angioedema related to previous treatment with an angiotensin converting enzyme inhibitor and in patients with hereditary or idiopathic angioedema. Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs.
ZESTORETIC Common Side Effects
Common side effects of ZESTORETIC:
- Dizziness
- Headache
- Cough
- Extreme tiredness
- Feeling lightheaded when standing after sitting or lying down
ZESTORETIC Serious Side Effects
Serious side effects are rare with ZESTORETIC. Contact your healthcare provider immediately if you experience any of the following.
- Angioedema (severe swelling): swelling of the face, arms or legs, lips, tongue, or throat
- Dangerously low blood pressure: dizziness, lightheadedness, pale skin, feeling faint
- Serious kidney problems: urinating less often than usual, swelling in your feet, ankles, or hands, unexplained weight gain
- Liver problems: yellowing of the skin or eyes, stomach pain, nausea, vomiting, confusion
- High blood potassium levels: nausea, muscle weakness, abnormal heartbeat
- Severe allergic reaction: swelling of your lips, tongue, throat, or face, trouble breathing, rash
Effects of other drugs, drug classes and over-the-counter products on ZESTORETIC
The following medications may interact with ZESTORETIC:
- Diuretics: Excessive drop in blood pressure.
- Antidiabetics: Increased risk of hypoglycaemia.
- NSAIDS: Increased risk of renal impairment and loss of antihypertensive efficacy
- Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension and hyperkalemia
- Potassium supplements/potassium-sparing diuretics: hyperkalemia
- Do not exceed doses greater than 20 mg daily of simvastatin
- mTOR inhibitors: increased risk of angioedema.
- Neprilysin inhibitors: increased risk of angioedema.Alcohol, barbiturates, or narcotics: Potentiation of orthostatic hypotension may occur.
- Cholestyramine and colestipol resins: Cholestyramine and colestipol resins bind the hydrochlorothiazide and reduce its absorption
- Corticosteroid, ACTH: Possible electrolyte depletion, particularly hypokalemia
- Pressor amines (e.g., norepinephrine): Possible decreased response to pressor amines.
- Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine): Possible increased responsiveness to the muscle relaxant
- Lithium: Generally should not be given with diuretics.
Who makes ZESTORETIC?
AstraZeneca
Is ZESTORETIC safe in pregnancy?
When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, ZESTORETIC should be discontinued as soon as possible.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ZESTORETIC prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ZESTORETIC prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ZESTORETIC savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ZESTORETIC savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ZESTORETIC | Canadian Prescription Savings* for ZESTORETIC | ZESTORETIC Drug Coupon* | ZESTORETIC Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ZESTORETIC?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ZESTORETIC | Canadian Prescription Savings* for ZESTORETIC | ZESTORETIC Drug Coupon* | ZESTORETIC Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ZESTORETIC savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ZESTORETIC drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ZESTORETIC, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ZESTORETIC prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ZESTORETIC is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ZESTORETIC for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ZESTORETIC prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ZESTORETIC prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ZESTORETIC
If you are having trouble paying for your ZESTORETIC medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ZESTORETIC you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ZESTORETIC is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ZESTORETIC
- If ZESTORETIC is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ZESTORETIC
If you are having trouble paying for your ZESTORETIC medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ZESTORETIC you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ZESTORETIC
- If ZESTORETIC is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ZESTORETIC
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ZESTORETIC treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ZESTORETIC you will need to meet the following criteria:
- You must be currently insured and have coverage for ZESTORETIC
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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