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ZESTORETIC

ZESTORETIC ®

Coupons, Savings & Patient Assistance

Learn more about ZESTORETIC® and see what savings options may be available to you that can help bring down the cost of your medication.

Options may include Rx Advantage Card, Copay assistance & Coupons, or Patient Assistance Programs. Suitable for insured, underinsured or uninsured individuals. Pay as little as $0 per fill.

Manufactured by AstraZeneca.

This content is intended for US audiences only

Drug savings programs

  • Qualified

    Rx Advantage Card for ZESTORETIC®

    Good News! You can save up to 90% on the cost of your ZESTORETIC® when using the FREE NowPatient’s Rx Advantage Card at your local pharmacy.

    A person holding a RX Savings Card
  • Available

    Canada drug option for ZESTORETIC®

    N/A
    Manufactured by
    N/A
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    Check eligibility
  • Unavailable

    Copay Assistance for ZESTORETIC®

    Unfortunately, AstraZeneca who manufactures ZESTORETIC®, does not offer a co-pay assistance program at this time. Please check back regularly as this situation may change.

    A person holding a coupon or copay card
    Option Not Available
  • Unavailable

    Patient Assistance Programs for ZESTORETIC®

    Unfortunately, AstraZeneca who manufactures ZESTORETIC®, does not offer a patient assistance program at this time. Please check back regularly as this situation may change.

    A picture of a patient assistance application form
    Option Not Available
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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about ZESTORETIC

What is ZESTORETIC?

What is ZESTORETIC?

ZESTORETIC is the brand name for lisinopril/hydrochlorothiazide and is available as an oral tablet.

What dosages is ZESTORETIC available in?

What dosages is ZESTORETIC available in?

ZESTORETIC contains lisinopril/hydrochlorothiazide and is a available as 10 mg/12. 5 mg, 20 mg/12.5 mg, and 20 mg/25 mg 30 mg oral tablet.

What is ZESTORETIC used for?

What is ZESTORETIC used for?

ZESTORETIC is an ACE inhibitor/thiazide diurectic that is used to treat high blood pressure.

How does ZESTORETIC work?

How does ZESTORETIC work?

ZESTORETIC is a combination of two medications that work together to lower blood pressure. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor. It relaxes your blood vessels by blocking a protein (ACE) that normally squeezes your blood vessels. Hydrochlorothiazide is a thiazide diuretic (water pill). It works in your kidneys to remove extra water and certain electrolytes (like sodium and potassium). This helps lower blood pressure.

How do I take ZESTORETIC?

How do I take ZESTORETIC?

ZESTORETIC is typically started at 10 mg/12.5 mg (lisinopril/hydrochlorothiazide) by mouth once daily. Your provider will adjust your dose based on how well it’s helping your blood pressure and if you’re having side effects. The maximum dose is 80 mg/50 mg (lisinopril/hydrochlorothiazide) once daily.

Is it safe for me to take ZESTORETIC?

Is it safe for me to take ZESTORETIC?

ZESTORETIC is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

You should not use this medication if you are hypersensitive to this product and have a history of angioedema related to previous treatment with an angiotensin converting enzyme inhibitor and in patients with hereditary or idiopathic angioedema. Because of the hydrochlorothiazide component, this product is contraindicated in patients with anuria or hypersensitivity to other sulfonamide-derived drugs.

ZESTORETIC Common Side Effects

ZESTORETIC Common Side Effects

Common side effects of ZESTORETIC:

  • Dizziness
  • Headache
  • Cough
  • Extreme tiredness
  • Feeling lightheaded when standing after sitting or lying down
ZESTORETIC Serious Side Effects

ZESTORETIC Serious Side Effects

Serious side effects are rare with ZESTORETIC. Contact your healthcare provider immediately if you experience any of the following.

  • Angioedema (severe swelling): swelling of the face, arms or legs, lips, tongue, or throat
  • Dangerously low blood pressure: dizziness, lightheadedness, pale skin, feeling faint
  • Serious kidney problems: urinating less often than usual, swelling in your feet, ankles, or hands, unexplained weight gain
  • Liver problems: yellowing of the skin or eyes, stomach pain, nausea, vomiting, confusion
  • High blood potassium levels: nausea, muscle weakness, abnormal heartbeat
  • Severe allergic reaction: swelling of your lips, tongue, throat, or face, trouble breathing, rash
Effects of other drugs, drug classes and over-the-counter products on ZESTORETIC

Effects of other drugs, drug classes and over-the-counter products on ZESTORETIC

The following medications may interact with ZESTORETIC:

  • Diuretics: Excessive drop in blood pressure.
  • Antidiabetics: Increased risk of hypoglycaemia.
  • NSAIDS: Increased risk of renal impairment and loss of antihypertensive efficacy
  • Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension and hyperkalemia
  • Potassium supplements/potassium-sparing diuretics: hyperkalemia
  • Do not exceed doses greater than 20 mg daily of simvastatin
  • mTOR inhibitors: increased risk of angioedema.
  • Neprilysin inhibitors: increased risk of angioedema.Alcohol, barbiturates, or narcotics: Potentiation of orthostatic hypotension may occur.
  • Cholestyramine and colestipol resins: Cholestyramine and colestipol resins bind the hydrochlorothiazide and reduce its absorption
  • Corticosteroid, ACTH: Possible electrolyte depletion, particularly hypokalemia
  • Pressor amines (e.g., norepinephrine): Possible decreased response to pressor amines.
  • Skeletal muscle relaxants, nondepolarizing (e.g., tubocurarine): Possible increased responsiveness to the muscle relaxant
  • Lithium: Generally should not be given with diuretics.
Who makes ZESTORETIC?

Who makes ZESTORETIC?

AstraZeneca

Is ZESTORETIC safe in pregnancy?

Is ZESTORETIC safe in pregnancy?

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, ZESTORETIC should be discontinued as soon as possible.

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What to do if you missed your ZESTORETIC ® dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects

What can I do if I am commercially insured but cannot afford my ZESTORETIC ®?

If you are commercially insured and you cannot afford your ZESTORETIC® copay or co-insurance you have four options:

Option

Savings Information

Copay Assistance Program

Check at the top of the page to see if there is a ZESTORETIC® Copay Assistance Program sponsored by the manufacturer. You can check your eligibility to see if you qualify. If you qualify you could obtain your ZESTORETIC® for as little as $0 per fill.

Patient Assistance Program

Check at the top of the page to see if there is a ZESTORETIC® Patient Assistance Program sponsored by the manufacturer. You can check your eligibility to see if you qualify. If you qualify you could obtain your ZESTORETIC® for no cost.

Rx Advantage Card

You can use the NowPatient Rx Advantage Card which removes the constraints of insurance and the cost can be typically lower than your plan copay or co-insurance. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

Medicaid

If the above options are not feasible then you can check Medicaid eligibility in your state by following this link to the HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

What can I do if I am uninsured and cannot afford my ZESTORETIC ®?

If you are uninsured and you cannot afford your ZESTORETIC®, then you have three options:

Option

Savings Information

Patient Assistance Program

Check at the top of the page to see if there is a ZESTORETIC® Patient Assistance Program sponsored by the manufacturer. You can check your eligibility to see if you qualify. If you qualify you could obtain your ZESTORETIC® for no cost.

Rx Advantage Card

You can use the NowPatient Rx Advantage Card at a local pharmacy and obtain prices that are typically 80% of standard retail prices.

Medicaid

If the above options are not feasible then you can check Medicaid eligibility in your state by following this link to the HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

What can I do if I am insured with Medicare and cannot afford my ZESTORETIC ®?

If you are insured with Medicare and have Part D or an Advantage drug plan but cannot afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you have four options:

Option

Savings Information

Patient Assistance Program

Check at the top of the page to see if there is a ZESTORETIC® Patient Assistance Program sponsored by the manufacturer. You can check your eligibility to see if you qualify. If you qualify you could obtain your ZESTORETIC® for no cost.

Rx Advantage Card

You can use the NowPatient Rx Advantage Card which removes the constraints of insurance and the cost can be typically lower than your plan copay or co-insurance. If you elect to use this method, out of pocket costs do not contribute towards your plan deductibles.

Low Income Subsidy

If this is still too expensive or unaffordable then you can apply for federal support like Low Income Subsidy (LIS). To be eligible for Low Income Subsidy, you need to be resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).

Medicaid

The final option is to check ‘dual eligibility’ to Medicaid in your state by following this link to the HealthCare.gov. The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.

Am I eligible for the Rx Advantage Card and how much does ZESTORETIC ® cost without insurance?

Our website gives savings options to customers who wish to purchase ZESTORETIC®, as either a brand or generic, without the constraints of insurance. By using the Rx Advantage Card, users can save up to 90% on the cost of their medication. The card can be used at over 65,000 pharmacies nationwide, across America. Even if you are insured, in most cases the cash price will be significantly cheaper than your existing co-pay. NowPatient is able to negotiate discounts on bulk drug purchases with pharmacy owners meaning you can access lower medication prices at nearby pharmacies using our card that can be conveniently stored in your NowPatient account.

What will my out-of-pocket cost be for ZESTORETIC ® when using the Rx Advantage Card?

Your out-of-pocket (OOP) cost will effectively be the discounted cash price you pay for ZESTORETIC® using the Rx Advantage Card. If you are insured, your OOP expense can not be used against your plan deductible, if your plan has a deductible.

Is it legal for me to pay cash for ZESTORETIC ® even though I have insurance?

Yes. The Rx Advantage card is especially useful for people who have High-deductible health plans (HDHPs). It can be used for insured, uninsured, and underinsured persons.

Does the Rx Advantage Card work with Medicare or any other federal or state insurance plans?

No. We do not bill any federal or state insurance including Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug benefit). When you purchase your medication using the NowPatient Rx Advantage Card, you will be doing so out of pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket ZESTORETIC® cash price you pay can be typically cheaper than your plan copay.

Does the Rx Advantage Card work with Commercial Insurance?

We do not bill your commercial insurance. When you purchase your medication using the Rx Advantage Card, from NowPatient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps in the event you have a plan with a deductible. The out-of-pocket ZESTORETIC® cash price you pay can be typically cheaper than your plan copay.

How do I check prices for ZESTORETIC ® and how do I use the Rx Advantage Card?

You can search for the prices at nearby pharmacies using our website. Simply search your medication and enter your ZIP Code and we will show you the price of your drug at nearby pharmacies. If you are happy with the quote, you need to create an account with NowPatient and generate your card. Next, simply go to the pharmacy and fill your ZESTORETIC® Rx. Ask the pharmacy to run the card and check the price, even if they tell you they have another card they use. Your card is stored safely in your NowPatient account.

Do I need to pay for the Rx Advantage Card?

No. The Rx Advantage prescription savings card is FREE to use and store for NowPatient users.

Is there a ZESTORETIC ® co-pay program?

You can check the top of the page to see if there is an option for a ZESTORETIC® co-pay card. Co-pay cards are programs run by pharmaceutical companies that offer you a direct way to lower your out-of-pocket costs for prescription drugs for eligible patients. The copay cards essentially allow physicians to prescribe medications that are clinically preferred.

What are the eligibility requirements for a ZESTORETIC ® co-pay card and how much do I have to pay?

Eligibility requirements vary between pharmaceutical companies. However, they almost all require you to be commercially insured. If you qualify there is no cost to you. It is a FREE program.

Can I enroll in the ZESTORETIC ® co-pay program if I have state, federal, or other government insurance?

Most likely, no. The copay card program is primarily designed for commercially or privately insured individuals. However, if you are finding it difficult to afford your medication, then there are other forms of assistance. For example, you can apply for LIS (Low Income Subsidy) or extra help is available online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778). As well, you can look at state assistance programs like Medicaid.

Can I enroll in the ZESTORETIC ® co-pay program if I have no insurance?

Most likely No. However, many pharmaceutical companies offer fully funded free programs for uninsured persons. These programs are called Patient Assistance Programs (PAP) and NowPatient provides a useful resource to check program availability and eligibility.

How can I check if I am eligible for the ZESTORETIC ® co-pay program?

If a ZESTORETIC® co-pay card exists, you will see it as a savings option at the top of the page. You can select the option and it will direct you to an eligibility checker. If you qualify you will be prompted to create an account with NowPatient, from where you will be able to access the instructions on how to enroll.

How do I use the ZESTORETIC ® co-pay card?

Once you are enrolled into the program you will be able to download the card. When you next fill your Rx, simply present the co-pay card to the pharmacist. The Pharmacist will use the card to process and submit your claim. You will then be provided with your discount. The program cost is covered by the pharmaceutical company.

Is there a ZESTORETIC ® Patient Assistance Program (PAP)?

You can check the top of the page to see if there is an option for a ZESTORETIC patient assistance program. PAPs are programs that are run and sponsored by pharmaceutical companies. They offer uninsured, insured, or underinsured individuals access to high-cost brand-name medications, which may otherwise be unaffordable.

What are the eligibility requirements for a ZESTORETIC ® PAP and how much do I have to pay?

Eligibility requirements vary between pharmaceutical companies. However, they almost all require you to be uninsured, underinsured with no drug coverage, or insured but unable to afford your co-pay or co-insurance contribution. If you qualify there is no cost to you. It is a FREE program funded by the pharmaceutical company.

Can I enroll in a ZESTORETIC ® PAP if I have state, federal, or other government insurance?

It is possible. Some programs do not allow any insured individuals to apply, however, some programs do have exceptions. If you find that you do not qualify and are finding it difficult to afford your medication, then there are other forms of assistance. For example, you can apply for LIS (Low Income Subsidy) or extra help is available online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778). As well, you can look at state assistance programs like Medicaid.

Can I enroll in a ZESTORETIC ® PAP if I have no insurance?

Yes. Most programs are open to individuals who are uninsured and meet income eligibility criteria.

How can I check if I am eligible for the ZESTORETIC ® PAP?

If a ZESTORETIC® patient assistance program exists, you will see it as a savings option at the top of the page. You can select the option and it will direct you to an eligibility checker. If you qualify you will be prompted to create an account with NowPatient, from where you will be able to access the instructions on how to enroll.

How do I use the ZESTORETIC ® PAP to obtain my medication?

Once you are enrolled in the program you will be advised by the pharmaceutical company how they will make supplies to you. In most cases, they will ship the medication through their nominated mail-order pharmacy, directly to you. However, depending on the nature of the medication, the pharmaceutical company may opt to provide you with a pharmacy card (which you can redeem against your medication for FREE at your nearby pharmacy) or ship the medication directly to your healthcare provider (HCP).

Refills are usually handled by the pharmaceutical company.

I am insured but I do not qualify for patient assistance or copay assistance for ZESTORETIC ®. Is there any other form of assistance that can help with the costs of my existing copays or co-insurance?

There are a number of resources available such as charitable foundations that may be able to provide assistance for your ZESTORETIC®:

Patient Access Network Foundation (PAN) assistance for ZESTORETIC®

If you are having trouble paying for your ZESTORETIC® medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ZESTORETIC® you will need to meet one or all of the following criteria:

  • Your income is below 400% of the federal poverty level
  • ZESTORETIC® is prescribed for an approved FDA indication
  • You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
  • You have Medicare insurance coverage that covers ZESTORETIC®
  • If ZESTORETIC® is listed on PAN's list of covered medications

You can check the Patient Access Network Foundation Website for more information.

HealthWell Foundation Copay Program for ZESTORETIC®

If you are having trouble paying for your ZESTORETIC® medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ZESTORETIC® you will need to meet the following criteria:

  • You live in and are being treated in the United States
  • You are insured and your plan covers ZESTORETIC®
  • If ZESTORETIC® is listed on the HealthWell Foundation's list of covered medications

You can check the HealthWell Foundation Website for more information.

Patient Advocate Foundation Co-Pay Relief Program for ZESTORETIC®

Patient Advocate Foundation's Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ZESTORETIC® treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ZESTORETIC® you will need to meet the following criteria:

  • You must be currently insured and have coverage for ZESTORETIC®
  • You must have a confirmed diagnosis and treatment plan
  • You must reside and receive treatment in the United States
  • Your Income must fall at or below 3000r 4000f the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
  • Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.

You can check the Patient Advocate Foundation Website for more information.

Can I buy my ZESTORETIC ® from Canada?

Americans pay at least twice as much (in fact 218%) on prescription medications than individuals in other countries, like Canada. The reason why Canada drugs are cheaper is that Canada regulates its prescription medication drug prices (the Patented Medicines Prices Review Board) meaning that consumers pay less for their ZESTORETIC®. This prevents pharmaceutical patentees from charging excessive prices.

As well, many Canadian drugs are likely produced by exactly the same companies in the same factories, as US prescription drugs.

We have partnered with Prescription Help in Canada that carries thousands of branded and generic medications. If there is an option for ZESTORETIC® from Canada, then we will provide this as an Rx savings option to you.

Is it safe for me to buy my ZESTORETIC ® from Prescription Help, Canada?

If you purchase ZESTORETIC® from Canadian Prescription Help, then there is little reason to worry about safety since it is likely that the drugs will be the same ones you would get from your American drugstore, and would have undergone the same rigorous testing as the American counterparts. Canada drugs are regulated for safety, efficacy and quality by Health Canada, which is the Canadian equivalent of the Food and Drug Administration (FDA). If you are unsure, you can discuss this option with your physician, especially if you find it difficult affording your medications and may therefore risk not being treated.

Rest assured, NowPatient has done thorough due diligence on Prescription Help, to ensure that the service is adequately licensed, regulated and safe.

We have checked and verified that Prescription Help:

  • Is a licensed pharmacy in Canada.
  • Will only fill your ZESTORETIC® if you have a valid prescription.
  • Has a licensed pharmacist on staff to answer your questions.
  • Does not send medicine that looks different than what you receive at your usual drug store, nor does it arrive in packaging that is damaged, in a foreign language, has no expiration date, or is expired.
  • Does not charge you for products that you never ordered or received.
  • Provides clear written protections for your personal and financial information, including credit card numbers.
  • Maintains the highest standards of data security and compliance.
  • Does not sell your information to other websites.
  • Does not supply controlled substances.
  • Does not supply any products on an FDA Import Alert.
  • Quantities are restricted to a maximum of 3 month's supply for international orders.
  • Publishes contact information on website for customer service.

Is ordering ZESTORETIC ® from a Canadian Pharmacy legal?

Although it is technically not legal for individuals to import prescription drugs, It is notable that U.S. government officials have stated that individuals who procure non-controlled prescription drugs from Canada or other foreign sources for up to a three-month supply for their own use are not pursued or prosecuted. There are hundreds of thousands of American patients who have used or continue to use Canadian pharmacies to procure their medications at significant discounts. Often the price of medications can be the difference between getting treated or not being treated.

How do I place an order for ZESTORETIC ® from Prescription Help, Canada?

If your medication is available from our partner Canadian Pharmacy, then we will show it as an option. You can search for the product by pack size, strength or form and then see the price for ZESTORETIC®. If you are happy with the price, you can proceed to the checkout. This will take you to the Prescription Help website, from where you can complete the process. Prescription Help is not connected to NowPatient other than as an affiliate partner which offers services that may benefit NowPatient users. It is not insurance, any payments are strictly cash and are considered out-of-pocket.

What should I do if I take too much ZESTORETIC ®?

Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using ZESTORETIC®. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you've used too much ZESTORETIC®. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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