Used for Cancer

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Manufactured by GlaxoSmithKline

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

ZEJULA Uses, Side Effects, Interactions, Warnings & Dosing

What is ZEJULA?

What is ZEJULA?

ZEJULA is the brand name for niraparib and is available as an oral capsule.

What dosages is ZEJULA available in?

What dosages is ZEJULA available in?

ZEJULA is available as a 100 mg oral capsule.

What is ZEJULA used for?

What is ZEJULA used for?

ZEJULA is a PARP inhibitor and is used for the following:
Maintenance treatment for advanced ovarian, fallopian tube, or primary peritoneal cancer that’s responded to chemotherapy
Maintenance treatment for recurrent ovarian, fallopian tube, or primary peritoneal cancer with BRCA mutations that’s responded to chemotherapy

How does ZEJULA work?

How does ZEJULA work?

ZEJULA is a PARP inhibitor, which means it stops the PARP protein in the body from working. The PARP protein normally helps cells, including cancer cells, grow and survive by fixing damaged DNA. By blocking PARP from working, ZEJULA prevents cancer cells from repairing their DNA, which kills them.

How do I take ZEJULA?

How do I take ZEJULA?

ZEJULA is dosed as follows:

Maintenance treatment for advanced ovarian cancer:

  • Weighing less than 77 kg (170 lbs) OR with a platelet level of less than 150,000/mcL: The typical dose is 200 mg by mouth once a day
  • Weighing 77 kg (170 lbs) or more AND with a platelet level of 150,000/mcL or more: The typical dose is 300 mg by mouth once a day
  • Maintenance treatment for recurrent ovarian cancer with BRCA mutations: The typical dose is 300 mg by mouth once a day

Your dose might be different if you have liver problems or experience side effects from the medication.

Is it safe for me to take ZEJULA?

Is it safe for me to take ZEJULA?

ZEJULA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

ZEJULA Common Side Effects

ZEJULA Common Side Effects

Common side effects of ZEJULA:

  • Nausea
  • Low platelet count
  • Low red blood cells
  • Tiredness
  • Constipation
  • Muscle, bone, or joint pain
  • Stomach pain
  • Vomiting
  • Poor appetite
ZEJULA Serious Side Effects

ZEJULA Serious Side Effects

Serious side effects are rare with ZEJULA. Contact your healthcare provider immediately if you experience any of the following.

  • Bone marrow problems: infections, fever, trouble breathing, weight loss, bleeding or bruising more easily, blood in the urine or stool, weakness
  • Extremely high blood pressure: headache, dizziness, nosebleeds
  • Posterior reversible encephalopathy syndrome (PRES): severe headaches, seizures, confusion, changes in vision
Effects of other drugs, drug classes and over-the-counter products on ZEJULA

Effects of other drugs, drug classes and over-the-counter products on ZEJULA

There are no major drug interactions listed for ZEJULA. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Who makes ZEJULA?

Who makes ZEJULA?


Is ZEJULA safe in pregnancy?

Is ZEJULA safe in pregnancy?

ZEJULA can harm your unborn baby and may cause
loss of pregnancy (miscarriage). If you are able to become pregnant, your healthcare provider may perform a pregnancy test before you start treatment with ZEJULA. Females who are able to become pregnant should use effective birth control (contraception)during treatment with ZEJULA and for 6 months after the last dose of ZEJULA. Talk to your healthcare provider about birth control methods that may be right for you. Tell your healthcare provider right away if you become pregnant.


What to do if you missed your ZEJULA dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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