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Xultophy 100/3.6 is the brand name for insulin degludec/liraglutide and is available as a subcutaneous injection.

Xultophy 100/3.6 contains 100 units/mL of insulin degludec and 3.6 mg/mL of liraglutide in a 3 mL single-patient-use pen.

Xultophy 100/3.6 is a premixed injection that combines two medications to manage blood sugar levels in adults with Type 2 diabetes.

Xultophy 100/3.6 is a combination of two medications that work together to lower blood sugar:

• Insulin degludec is a long-acting insulin. It helps control blood sugar levels throughout the day by helping your body absorb and store sugar from the bloodstream after a meal.
• Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor agonist. It activates GLP-1, a hormone that tells your pancreas to release more insulin, your liver to make less sugar, and makes you feel full longer by slowing down how quickly food leaves the stomach.

Administer Xultophy 100/3.6 once daily at same time each day with or without food. The maximum daily dosage is 50 units (50 units of insulin degludec and 1.8 mg of liraglutide).

Xultophy 100/3.6 is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Patients with a personal or family history of medullary thyroid carcinoma or in patients with Multiple Endocrine Neoplasia syndrome type 2.
• During episodes of low blood sugar
• Patients with a serious hypersensitivity reaction to insulin degludec, liraglutide, or any of the excipients in the product

Common side effects of Xultophy 100/3.6:

• Low blood sugar
• Common cold or flu symptoms
• Headache
• Nausea
• Diarrhea
• Rise in a pancreas enzyme (lipase)

Serious side effects are rare with Xultophy 100/3.6. Contact your healthcare provider immediately if you experience any of the following:

• Thyroid cancer: mass in the neck, trouble breathing or swallowing, hoarseness
• Inflammation of the pancreas (pancreatitis): severe stomach pain that spreads to your back, nausea, vomiting
• Severely low blood sugar: dizziness, shakiness, feeling confused, feeling irritable or anxious, feeling faint, sweating, extreme hunger, can’t think clearly
• Kidney damage: tiredness, dry and itchy skin, urinating more often, bloody or foamy urine, swelling in your feet or ankles, muscle cramping
• Dangerously low potassium levels: weakness, muscle cramps or twitches, constipation, abnormal heartbeat, tiredness, trouble breathing
• Gallbladder problems: severe upper stomach and back pain, yellowing of your skin or eyes (jaundice), fever, nausea, vomiting
• Heart failure: shortness of breath, tiredness, swelling in your legs, ankles, or feet, sudden weight gain
• Severe allergic reaction: rash; hives; swelling of face, tongue, and throat; trouble breathing

The following medications may interact with Xultophy 100/3.6:

• Drugs that affect glucose levels
• Anti-adrenergic drugs (e.g., beta-blockers, clonidine, guanethidine, and reserpine)
• Some oral medications

Novo Nordisk Inc.

Xultophy 100/3.6 should be used during pregnancy only if the potential benefit justifies the potential risk to the unborn baby. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Insulin Degludec/Liraglutide