Used for Osteoporosis

View XGEVA savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or XGEVA Patient Assistance Program.

Programs are suitable for individuals who want to buy XGEVA without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Amgen Inc.

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about XGEVA

What is XGEVA?

What is XGEVA?

XGEVA is the brand name for denosumab subcutaneous injection.

What dosages is XGEVA available in?

What dosages is XGEVA available in?

XGEVA is available as 120 mg/1.7 mL (70 mg/mL) solution in a single-dose vial.

What is XGEVA used for?

What is XGEVA used for?

XGEVA is a monoclonal antibody and is used for the following:

  • Prevention of broken bones in people with multiple myeloma or cancer that has spread to the bones
  • Bone tumors called giant cell tumor of bone in adults and teenagers who can’t have the tumors removed by surgery
  • High calcium levels caused by cancer
How does XGEVA work?

How does XGEVA work?

XGEVA is a monoclonal antibody. It blocks a protein found in some tumors that tells your body to break down your bones and causes your tumor to grow. This slows down the breakdown of your bones, which lowers your risk of broken bones.

How do I take XGEVA?

How do I take XGEVA?

XGEVA is dosed as follows:

  • People with multiple myeloma or cancer that has spread to the bone: The typical dose is 120 mg injected under the skin of the upper arm, upper thigh, or stomach every 4 weeks
  • People with giant cell tumor of bone: The typical dose is 120 mg injected under the skin of the upper arm, upper thigh, or stomach every 4 weeks. An additional 120 mg is injected under the skin on days 8 and 15 during the first month of taking XGEVA
  • People with high calcium levels caused by cancer: The typical dose is 120 mg injected under the skin of the upper arm, upper thigh, or stomach every 4 weeks. An additional 120 mg is injected under the skin on days 8 and 15 during the first month of taking XGEVA
Is it safe for me to take XGEVA?

Is it safe for me to take XGEVA?

XGEVA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

  • Hypocalcemia
  • Known clinically significant hypersensitivity to XGEVA
XGEVA Common Side Effects

XGEVA Common Side Effects

Common side effects of XGEVA:

  • Fatigue or weakness
  • Low phosphorus levels
  • Low calcium levels
  • Low red blood cell count
  • Low platelet count
  • Diarrhea
  • Constipation
  • Nausea
  • Vomiting
  • Back pain
  • Joint pain
  • Swelling (edema)
  • Common cold
  • Shortness of breath
  • Rash
  • Headache
  • Low appetite
XGEVA Serious Side Effects

XGEVA Serious Side Effects

Serious side effects are rare with XGEVA. Contact your healthcare provider immediately if you experience any of the following.

  • Serious allergic reactions: low blood pressure, shortness of breath, tightness in your throat, swelling in your face and throat, itchiness, rash
Effects of other drugs, drug classes and over-the-counter products on XGEVA

Effects of other drugs, drug classes and over-the-counter products on XGEVA

There are no major drug interactions listed for XGEVA. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Who makes XGEVA?

Who makes XGEVA?

Amgen Inc.

Is XGEVA safe in pregnancy?

Is XGEVA safe in pregnancy?

Based on findings in animals and its mechanism of action, XGEVA can cause fetal harm when administered to a pregnant woman. Females who can become pregnant should use effective contraception during therapy, and for at least
5 months after the last dose of XGEVA.


What to do if you missed your XGEVA dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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