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Xgeva is the brand name for denosumab subcutaneous injection.

Xgeva is available as 120 mg/1.7 mL (70 mg/mL) solution in a single-dose vial.

Xgeva is a monoclonal antibody and is used for the following:

• Prevention of broken bones in people with multiple myeloma or cancer that has spread to the bones
• Bone tumors called giant cell tumor of bone in adults and teenagers who can’t have the tumors removed by surgery
• High calcium levels caused by cancer

Xgeva is a monoclonal antibody. It blocks a protein found in some tumors that tells your body to break down your bones and causes your tumor to grow. This slows down the breakdown of your bones, which lowers your risk of broken bones.

Xgeva is dosed as follows:

• People with multiple myeloma or cancer that has spread to the bone: The typical dose is 120 mg injected under the skin of the upper arm, upper thigh, or stomach every 4 weeks
• People with giant cell tumor of bone: The typical dose is 120 mg injected under the skin of the upper arm, upper thigh, or stomach every 4 weeks. An additional 120 mg is injected under the skin on days 8 and 15 during the first month of taking Xgeva
• People with high calcium levels caused by cancer: The typical dose is 120 mg injected under the skin of the upper arm, upper thigh, or stomach every 4 weeks. An additional 120 mg is injected under the skin on days 8 and 15 during the first month of taking Xgeva

Xgeva is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Hypocalcemia
• Known clinically significant hypersensitivity to Xgeva

Common side effects of Xgeva:

• Fatigue or weakness
• Low phosphorus levels
• Low calcium levels
• Low red blood cell count
• Low platelet count
• Diarrhea
• Constipation
• Nausea
• Vomiting
• Back pain
• Joint pain
• Swelling (edema)
• Common cold
• Shortness of breath
• Rash
• Headache
• Low appetite

Serious side effects are rare with Xgeva. Contact your healthcare provider immediately if you experience any of the following.

• Serious allergic reactions: low blood pressure, shortness of breath, tightness in your throat, swelling in your face and throat, itchiness, rash

There are no major drug interactions listed for Xgeva. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Amgen Inc.

Based on findings in animals and its mechanism of action, Xgeva can cause fetal harm when administered to a pregnant woman. Females who can become pregnant should use effective contraception during therapy, and for at least
5 months after the last dose of Xgeva.

• Denosumab