Key facts about Xerese
What is Xerese?
Xerese is the brand name for acyclovir and hydrocortisone as is available as a topical cream.
What dosages is Xerese available in?
Xerese is available as a topical cream that contains 5% of acyclovir and 1% of hydrocortisone.
What is Xerese used for?
Xerese is used to shorten the healing time and treat symptoms (tingling, pain, burning, itching) of repeated cold sores in people 6 years and older.
How does Xerese work?
Xerese is a combination of two medications. Acyclovir is an antiviral medication. It stops the herpes simplex virus (HSV) from making copies of itself. Hydrocortisone is a steroid. It lowers the amount of inflammatory chemicals that cause redness, itching, and swelling. This helps lower skin inflammation.
How do I take Xerese?
Apply Xerese to the affected area(s) 5 times a day for 5 days. Xerese cream contains acyclovir 5% and hydrocortisone 1%.
Is it safe for me to take Xerese?
Xerese is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
Xerese Common Side Effects
Side effects aren’t common with Xeresex. Other side effects include:
- Dry skin
- Burning or tingling feeling
- Skin redness
- Changes in skin color
- Skin inflammation
Xerese Serious Side Effects
Serious side effects are rare with Xerese. Contact your healthcare provider immediately if you experience any bothersome side effects that don’t go away.
Effects of other drugs, drug classes and over-the-counter products on Xerese
There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.
Who makes Xerese?
Bausch Health
Is Xerese safe in pregnancy?
It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.













