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Vedolizumab is available in the following:

• 300 mg Vedolizumab in a single-dose vial for IV infusion
• 108 mg/0.68 mL solution in a single-dose prefilled syringe or single-dose prefilled pen for subcutaneous injection

Vedolizumab is a monoclonal antibody used to treat ulcerative colitis (UC) and Crohn’s disease (CD) in adults.

Vedolizumab is an integrin antagonist. It works by blocking proteins found on immune cells called integrins. They play a role in causing inflammation in the gut related to ulcerative colitis and Crohn’s disease. By blocking integrin proteins, Vedolizumab helps reduce inflammation in the gut.

You will typically get your first two doses as a 300 mg infusion from your doctor.

Starting at week 6, you can keep geting or switch to injections under the skin.

As an infusion into the vein:

• The typical maintenance dose is 300 mg given IV once every 2 months.
• As an injection under the skin: The typical maintenance dose is 108 mg injected under the skin once every 2 weeks.

Vedolizumab is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Known serious or severe hypersensitivity reaction to Vedolizumab or any of its excipients.

Common side effects of Vedolizumab:

• Infection in nose and throat
• Headache
• Joint pain
• Nausea
• Fever
• Upper respiratory tract infection
• Fatigue
• Cough

Serious side effects are rare with Vedolizumab. Contact your healthcare provider immediately if you experience any of the following:

• Infusion-related reactions or allergic reactions: hives, rash, swelling of the face and around the eyes, trouble breathing, wheezing, trouble swallowing, vomiting, diarrhea, fast heart rate, passing out
• Infection: fever, trouble breathing, chills, sweating, weakness, cough, stomach pain, diarrhea, burning when you urinate, urinating more often
• Serious brain infection: weakness on one side of the body, clumsiness, changes in vision, changes in memory or thinking, changes in personality, confusion
• Liver problems: swelling of your stomach, stomach pain, loss of appetite, nausea, yellowing of your skin or the whites of your eyes, tiredness, confusion

The following medications may interact with Vedolizumab:

• Natalizumab products
• TNF blockers
• CYP450 substrates

Various FDA-approved generic manufacturers

There isn’t much information so far. But available data suggest that the medication doesn’t raise the risk of serious birth defects or miscarriage. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Entyvio