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Vanrafia is the brand name for atrasentan and is available as an oral tablet.

Vanrafia is available as a 0.75 mg oral tablet.

Vanrafia is used to lower protein levels in the urine in adults with immunoglobulin A nephropathy (IgAN).

Vanrafia is an endothelin receptor antagonist that blocks the effects of endothelin-1. Doing so helps reduce stress on the kidneys, which can lower the amount of protein that leaks into the urine.

The typical dose of Vanrafia is 0.75 mg by mouth once daily with or without food.

Vanrafia is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• Pregnancy
• Hypersensitivity

Common side effects of Vanrafia:

• Swelling of the arms or legs
• Low red blood cells (anemia)

Serious side effects are rare with Vanrafia. Contact your healthcare provider immediately if you experience any of the following:

• Serious liver problems: nausea, vomiting, pain in the upper right side of the stomach, decreased appetite, dark urine, yellowing of your skin or the whites of your eyes, tiredness, fever, itching
• Fluid buildup: unexplained weight gain, swelling in your ankles or legs, trouble breathing

The following medications may interact with Vanrafia:

• Strong or moderate CYP3A inducers
• OATP1B1/1B3 inhibitors

Novartis Pharmaceuticals

Vanrafia may cause major birth defects if used during pregnancy. Females who can become pregnant should have a negative pregnancy test before starting treatment. They should use effective birth control before starting Vanrafia, during treatment and for 2 weeks after stopping the medication.

• Atrasentan