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Unithroid is the brand name for levothyroxine sodium tablets.

Unithroid is available as a 25 mcg, 50 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg, 137 mcg, 150 mcg, 175 mcg, 200mcg, or 300 mcg oral tablet.

Unithroid is L-thyroxine (T4) indicated in pediatric and adult patients for:

• Hypothyroidism: As replacement in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired hypothyroidism (1)
• Pituitary Thyrotropin (Thyroid-Stimulating Hormone, TSH) Suppression: As an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer

Unithroid is a man-made version of the T4 thyroid hormone made by your thyroid gland. Thyroid hormones have important functions like controlling metabolism, body temperature, heart rate, and more. When the amount of hormone is too low, taking thyroid replacement hormones can bring your levels back to normal.

The starting dose of Unithroid depends on a variety of factors, including age, body weight, cardiovascular status, concomitant medical conditions (including pregnancy), concomitant medications, co-administered food, and the specific nature of the condition being treated. Peak therapeutic effect may not be attained for 4 to 6 weeks. It is typically taken once daily, on an empty stomach, one-half to one hour before breakfast with a full glass of water.

Unithroid is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have uncorrected adrenal insufficiency.

Common side effects of Unithroid:

• Side effects are rare and are typically related to too much thyroid hormone.
• Signs of having too much thyroid hormones in the body, include:
• Headache
• Anxiety or nervousness
• Trouble sleeping
• Tiredness
• Feeling very hungry
• Weight loss
• Sweating a lot
• Weak muscles
• Trouble breathing
• Rash
• Diarrhea
• Vomiting
• Stomach cramps

Serious side effects are rare with Unithroid. Contact your healthcare provider immediately if you experience any of the following.

• Heart failure: trouble breathing, weakness, tiredness, swelling in the hands, ankles, and feet
• Heart attack: dizziness, lightheadedness, anxiety, trouble breathing, fast heartbeat, nausea, cold sweat, clammy skin, chest pain or tightness

The following medications may interact with Unithroid:

• Many drugs can exert effects on thyroid hormone pharmacokinetics (e.g. absorption, synthesis, secretion, catabolism, protein binding, and target tissue response) and may alter the therapeutic response to Unithroid. See full prescribing information for drugs that affect thyroid hormone pharmacokinetics and metabolism (e.g., absorption, synthesis, secretion, catabolism, protein binding, and target tissue response) and may alter the therapeutic response to Unithroid

Jerome Stevens Pharmaceuticals

Experience with levothyroxine use in pregnant women, including data from post-marketing studies, have not reported increased rates of major birth defects or miscarriages. Unithroid should not be discontinued during pregnancy and hypothyroidism diagnosed during pregnancy should be promptly treated.

• Levothyroxine Sodium