TYKERB

Used for Cancer

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Manufactured by Novartis Pharmaceuticals

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

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    Save up to 90%

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    Patient Assistance Programs

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    FREE

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

TYKERB Uses, Side Effects, Interactions, Warnings & Dosing

What is TYKERB?

What is TYKERB?

TYKERB is the brand name for lapatinib and is available as an oral tablet.

What dosages is TYKERB available in?

What dosages is TYKERB available in?

TYKERB is available as a 250 mg oral tablet.

What is TYKERB used for?

What is TYKERB used for?

TYKERB is a tyrosine kinase inhibitor that is used to treat:

  • HER2-positive metastatic breast cancer
  • HR-positive, HER2-positive metastatic breast cancer
How does TYKERB work?

How does TYKERB work?

TYKERB is a tyrosine kinase inhibitor (TKI). It works by blocking the action of specific proteins called human epidermal growth factor receptor 2 (HER2) and epidermal growth factor receptor (EGFR). HER2 and EGFR are both found on normal and cancer cells, and they play a role in cell growth. In certain cancers, the cancer cells have more HER2 and EGFR proteins than normal cells. When these proteins are blocked by TYKERB, cancer cells can’t grow and spread as well.

How do I take TYKERB?

How do I take TYKERB?

TYKERB is dosed as follows:

  • HER2-positive metastatic breast cancer: The typical dose is 5 tablets (total of 1,250 mg of lapatinib) taken by mouth at one time every day
  • HR-positive, HER2-positive metastatic breast cancer: The typical dose is 6 tablets (total of 1,500 mg of lapatinib) taken by mouth at one time every day

Your dose might be different if you have liver problems.

Is it safe for me to take TYKERB?

Is it safe for me to take TYKERB?

TYKERB is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

TYKERB Common Side Effects

TYKERB Common Side Effects

Common side effects of TYKERB:

  • Diarrhea
  • Rash
  • Hand-foot syndrome
  • Nausea
  • Infection around the nails
  • Vomiting
  • Tiredness
  • Lowered appetite
  • Inflammation or reddening inside of the mouth
TYKERB Serious Side Effects

TYKERB Serious Side Effects

Serious side effects are rare with TYKERB. Contact your healthcare provider immediately if you experience any of the following.

  • Severe diarrhea
  • Liver problems: yellowing of skin or whites of your eyes, dark-colored urine, right upper stomach pain or discomfort, itchy skin
  • Severe skin reactions: blisters on the skin, peeling skin, red skin, rash that keeps getting worse
Effects of other drugs, drug classes and over-the-counter products on TYKERB

Effects of other drugs, drug classes and over-the-counter products on TYKERB

The following medications may interact with TYKERB:

  • TYKERB is likely to increase exposure to concomitantly administered drugswhich are substrates of CYP3A4,  or P-glycoprotein (ABCB1)
  • Avoid strong CYP3A4 inhibitors. If unavoidable, consider dose reduction of TYKERB in patients coadministered a strong CYP3A4 inhibitor
  • Avoid strong CYP3A4 inducers. If unavoidable, consider gradual dose increase of TYKERB in patients coadministered a strong CYP3A4 inducer
Who makes TYKERB?

Who makes TYKERB?

Novartis Pharmaceuticals

Is TYKERB safe in pregnancy?

Is TYKERB safe in pregnancy?

TYKERB can harm your unborn baby. Your healthcare provider should check to see if you are pregnant before you start taking TYKERB. You should use effective birth control
(contraception) during treatment with TYKERB and for 1 week after the last dose of TYKERB. Tell your healthcare
provider right away if you become pregnant during treatment with TYKERB.

For males with female partners who are able to become pregnant:

  • Use effective contraception during treatment with TYKERB and for 1 week after the last dose.
  • If your female partner becomes pregnant during treatment with TYKERB, tell your healthcare provider right away.
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What to do if you missed your TYKERB dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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