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Tukysa is the brand name for tucatinib and is available as an oral tablet.

Tukysa is available as a 50 mg and 150 mg oral tablet.

Tukysa is a kinase inhibitor used to treat advanced or metastatic HER2-positive breast cancer.

Tukysa is a tyrosine kinase inhibitor. It works by blocking the action of a protein called human epidermal growth factor receptor 2 (HER2). In HER2-positive breast cancer, the cancer cells typically have more HER2 proteins than normal cells. When this protein is blocked by Tukysa, cancer cells can’t grow and spread as well.

Tukysa is dosed as 300 mg by mouth twice daily with or without food.

Tukysa is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Tukysa when taken with other anticancer meds:

• Diarrhea
• Rash, redness, pain, or blisters on the palms of your hands or soles of your feet (hand-foot syndrome)
• Nausea
• Liver damage
• Vomiting
• Pain, sores, blisters, or inflammation in the mouth
• Lower appetite

Serious side effects are rare with Tukysa. Contact your healthcare provider immediately if you experience any of the following:

• Severe diarrhea
• Liver problems: yellowing of skin or whites of your eyes, dark-colored urine, right upper stomach pain or discomfort, itchy skin

The following medications may interact with Tukysa:

• CYP3A inducers and substrates
• CYP2C8 inhibitors
• P-gp substrates

Pfizer Inc.

Tukysa can harm your unborn baby. Females who can get pregnant should do a pregnancy test before you start treatment. You should use effective birth control (contraception) during treatment with Tukysa and for 1 week after the last dose. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment.

• Tucatinib