TRIJARDY XR
Used for Type 2 Diabetes
NowPatient helps you obtain your TRIJARDY XR prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by Boehringer Ingelheim Pharmaceuticals, Inc.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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TRIJARDY XR key facts
What is TRIJARDY XR?
TRIJARDY XR is the brand name for empagliflozin, linagliptin, and metformin and is available as an extended-release oral tablet.
What dosages is TRIJARDY XR available in?
TRIJARDY XR is available as an extended-release oral tablet that contains:
- 5 mg empagliflozin/2.5 mg linagliptin/1,000 mg metformin
- 10 mg empagliflozin/5 mg linagliptin/1,000 mg metformin
- 2.5 mg empagliflozin/2.5 mg linagliptin/1,000 mg metformin
- 25 mg empagliflozin/5 mg linagliptin/1,000 mg metformin
What is TRIJARDY XR used for?
- TRIJARDY XR is a SGLT2/DPP-4 inhibitor/biguanide combination that is used to treat type 2 diabetes
How does TRIJARDY XR work?
TRIJARDY XR is a combination of three diabetes medications that work together to lower your blood sugar:
Empagliflozin is a sodium glucose cotransporter 2 (SGLT2) inhibitor. It allows your body to get rid of excess sugar through the urine by lowering the amount of sugar that gets absorbed back into your kidneys. Linagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor that raises the amount of insulin your body makes. Metformin is a biguanide that lowers the amount of sugar your liver makes, lowers the amount of sugar your stomach absorbs, and helps you respond better to insulin.
How do I take TRIJARDY XR?
- The starting dose of TRIJARDY XR will depend on the doses of your previous diabetes medications. TRIJARDY XR should be taken by mouth once a day in the morning with a meal. Your provider might adjust your dose depending on how you respond to the medication. Don’t take more than 25 mg/5 mg/2,000 mg (empagliflozin/linagliptin/metformin) total per day
Is it safe for me to take TRIJARDY XR?
TRIJARDY XR is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Severe renal impairment (eGFR below 30 mL/min/1.73 m2), end-stage renal disease, or on dialysis.
- Metabolic acidosis, including diabetic ketoacidosis.
- Hypersensitivity to empagliflozin, linagliptin, metformin, or any of the excipients in TRIJARDY XR
TRIJARDY XR Common Side Effects
Common side effects of TRIJARDY XR:
- Upper respiratory tract infection
- Urinary tract infection
- Common cold
- Diarrhea
- Constipation
- Headache
- Stomach flu (gastroenteritis)
- Low blood sugar
- Frequent urination
TRIJARDY XR Serious Side Effects
Serious side effects are rare with TRIJARDY XR. Contact your healthcare provider immediately if you experience any of the following.
- Lactic acidosis (buildup of lactic acid): unusual muscle pain, difficulty breathing, unusual sleepiness, stomach pain, feeling cold in hands or feet, low blood pressure, slow heart rate, very weak or tired
- Pancreatitis (inflammation of the pancreas): severe stomach pain that doesn’t go away, pain that starts from the stomach and wraps to the back, sometimes vomiting
- Ketoacidosis (buildup of ketones): dehydration, nausea, vomiting, stomach pain, tiredness, shortness of breath
- Heart failure: shortness of breath, sudden fast weight gain, swelling of the feet
- Kidney problems: low urine production, swelling in the legs, nausea, tiredness, shortness of breath
- Fournier’s gangrene (flesh-eating bacterial infection of the genitals): fever or discomfort along with pain, tenderness, redness, or swelling in the genital area
Serious skin reactions: fluid-filled blisters, top layer of your skin looks like it’s breaking down - Serious allergic reactions: rash, hives, swelling of the face, lips, tongue, and throat that causes difficulty breathing or difficulty swallowing
Effects of other drugs, drug classes and over-the-counter products on TRIJARDY XR
The following medications may interact with TRIJARDY XR:
- Carbonic Anhydrase Inhibitors: May increase risk of lactic acidosis
- Consider more frequent monitoring
- Drugs that Reduce Metformin Clearance: May increase risk of lactic acidosis. Consider benefits and risks of concomitant use. See full prescribing information for additional drug interactions and information on interference of TRIJARDY XR with laboratory tests
Who makes TRIJARDY XR?
Boehringer Ingelheim Pharmaceuticals, Inc.
Is TRIJARDY XR safe in pregnancy?
Based on animal data showing adverse renal effects from empagliflozin, TRIJARDY XR is not recommended during the second and third trimesters of pregnancy. You should talk to your healthcare provider before taking this medication if you are pregnant.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my TRIJARDY XR prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your TRIJARDY XR prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient TRIJARDY XR savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient TRIJARDY XR savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for TRIJARDY XR | Canadian Prescription Savings* for TRIJARDY XR | TRIJARDY XR Drug Coupon* | TRIJARDY XR Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of TRIJARDY XR?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for TRIJARDY XR | Canadian Prescription Savings* for TRIJARDY XR | TRIJARDY XR Drug Coupon* | TRIJARDY XR Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the TRIJARDY XR savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the TRIJARDY XR drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for TRIJARDY XR, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the TRIJARDY XR prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, TRIJARDY XR is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed TRIJARDY XR for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the TRIJARDY XR prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the TRIJARDY XR prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for TRIJARDY XR
If you are having trouble paying for your TRIJARDY XR medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for TRIJARDY XR you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- TRIJARDY XR is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers TRIJARDY XR
- If TRIJARDY XR is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for TRIJARDY XR
If you are having trouble paying for your TRIJARDY XR medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for TRIJARDY XR you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers TRIJARDY XR
- If TRIJARDY XR is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for TRIJARDY XR
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your TRIJARDY XR treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for TRIJARDY XR you will need to meet the following criteria:
- You must be currently insured and have coverage for TRIJARDY XR
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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