TretinoinPrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Tretinoin
    Generic for Retin-A
    20g tube of creams $24 USD
    Save $56.90
  3. Tretinoin
    Generic for Retin-A
    20g tube of creams $26.52 USD
    Save $54.38
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Save up to 90% of your branded or generic medications using the Now Patient Rx Advantage Card

Do you need a prescription for tretinoin?

Yes, tretinoin is only available with a valid physician Rx.

How much is tretinoin without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase tretinoin, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for tretinoin in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a tretinoin savings card?

Yes. Save up to 90% on your tretinoin with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a tretinoin coupon provider in the US?

No. Now Patient does not provide tretinoin coupons or FREE tretinoin samples.

Do you accept commercial, Medicare or Medicaid coverage for tretinoin in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much tretinoin?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using tretinoin. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much tretinoin. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic tretinoin?

US brand name of tretinoin and manufacturer

Tretinoin is FDA-approved in the US under various brand names, including Retin-A, Renova, and Avita. It is manufactured by different pharmaceutical companies.

UK brand name of tretinoin and manufacturer

Tretinoin is not available as licensed product in the UK.

Is tretinoin available in the UK on the NHS?

Yes, tretinoin may be available on the NHS in the UK, as an unlicensed special.

Prescription requirement for tretinoin

Tretinoin is a prescription medication and requires a prescription from a healthcare provider.

Active ingredient of tretinoin and mechanism of action

Tretinoin belongs to a class of medications known as retinoids. Its active ingredient is a vitamin A (retinol) derivative called all-trans retinoic acid. Tretinoin works by increasing the production of collagen and regulating the turnover of skin cells. It helps to normalize the process of skin cell maturation and shedding, which can improve various skin conditions.

Uses of tretinoin

Tretinoin is primarily used topically for the treatment of acne vulgaris, both inflammatory and noninflammatory. It helps to unclog pores, reduce inflammation, and promote the turnover of skin cells, leading to clearer skin. Tretinoin is also used for the treatment of other skin conditions, such as photoaging, fine wrinkles, and certain types of hyperpigmentation.

Forms of tretinoin

Tretinoin is available in various formulations, such as topical retinoid creams, gels, and lotions, or as an oral medication called isotretinoin. The specific form and strength will depend on the intended use and the prescribing healthcare provider’s recommendations.

Dosage of tretinoin

The dosage of tretinoin will vary depending on the specific skin condition being treated and individual patient characteristics. It is important to follow the dosage instructions provided by your healthcare provider. Topical tretinoin is typically applied once daily as a thin layer to the affected areas of the skin, and it is recommended to start with a lower strength and gradually increase as tolerated.

Precautions and warnings for tretinoin

  • Tretinoin can cause skin irritation, such as redness, peeling, and dryness. It is important to use it as directed and avoid excessive sun exposure or other skin irritants. Your doctor may advise you to use moisturizer to reduce skin dryness
  • Tretinoin should not be used by pregnant women or those planning to become pregnant, as it may cause harm to the developing fetus. Adequate contraception should be used during treatment with tretinoin
  • It is important to inform your healthcare provider about any other medications you are using, as certain medications may interact with tretinoin and affect its effectiveness or increase the risk of side effects
  • Tretinoin can increase the skin’s sensitivity to sunlight. Avoid tanning booths and sunlamps. It is important to use sunscreen and protective clothing when exposed to the sun to prevent sunburn
  • It is not known if tretinoin passes into breast milk. Speak to your doctor before breast-feeding

Side effects of tretinoin

Common side effects of tretinoin may include skin irritation, dryness, peeling, change in skin pigmentation, and redness. These side effects are usually mild and resolve with continued use. However, if severe or persistent side effects occur, it is important to seek medical attention. Get medical help right away if you have a serious side effect such as an allergic reaction. Symptoms include hives, trouble breathing, worsening shortness of breath, sore throat, chest pain, swelling of the face, tongue or throat, red skin lesions, blisters, and serious skin reactions.

Interactions with other drugs

Tretinoin may interact with other topical medications or skincare products, especially benzoyl peroxide, salicylic acid, and dandruff shampoos containing sulfur or resorcinol. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medications, herbal products, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.


  • Retin-A (Tretinoin) Prescribing Information – Ortho Dermatologics.
  • Tretinoin – MedlinePlus.

About Now Patient

Now Patient’s online services are available in the US and UK. We help you manage your prescriptions, doctor appointments, test results, health risks, and a lot more, all in one place for FREE. If you are in the United States, you could enjoy savings using Now Patient’s mail-order pharmacy or use the Now Patient Rx Advantage Card at over 65,000 pharmacies, with savings of up to 90% on popular FDA-approved brand and generic medications like Ozempic, Mounjaro, clopidogrel and lots more. We do not currently handle commercial insurance, Medicare or Medicaid. UK NHS and private prescriptions are delivered FREE of charge across England & Wales by our UK NHS online pharmacy.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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