Used for Cancer

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

trametinib Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is trametinib available in?

What dosages is trametinib available in?

trametinib is available as a 0.5 mg and 2 mg oral tablet and a 4.7 mg oral solution.

What is trametinib used for?

What is trametinib used for?

trametinib is a MEK inhibitor and is used for the following:

  • Melanoma with certain BRAF mutations
  • Melanoma that has spread (metastatic) or can’t be removed by surgery, used by itself or with Tafinlar (dabrafenib)
  • Advanced melanoma, given after surgery and used with Tafinlar (dabrafenib)
  • Metastatic non-small cell lung cancer (NSCLC) with a certain BRAF mutation, used with Tafinlar (dabrafenib)
  • Metastatic anaplastic thyroid cancer (ATC) with a certain BRAF mutation, used with Tafinlar (dabrafenib)
  • Solid tumors with a certain BRAF mutation that have spread or can’t be removed by surgery, used with
  • Tafinlar (dabrafenib)
  • Low-grade glioma (LGG) with a certain BRAF mutation, used with Tafinlar (dabrafenib)
How does trametinib work?

How does trametinib work?

trametinib is a kinase inhibitor known as a MEK inhibitor. The MEK protein is part of a whole chain of proteins that work to help cells grow. By blocking MEK, this medication helps stop tumor growth. trametinib is taken together with an anticancer medication called Tafinlar (dabrafenib) that specifically targets another protein in this chain (the BRAF protein). When the BRAF protein is mutated, the cancer can grow uncontrollably and spread more quickly. By blocking two different proteins in this pathway, trametinib and Tafinlar (dabrafenib) work together to stop the growth and spread of cancer better.

How do I take trametinib?

How do I take trametinib?

trametinib is dosed as follows:

  • Adults: The typical dose is 2 mg by mouth once a day
  • Children: The dose depends on your child’s body weight. The typical dose ranges from 0.3 mg to 2 mg by mouth once a day
Is it safe for me to take trametinib?

Is it safe for me to take trametinib?

trametinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

trametinib Common Side Effects

trametinib Common Side Effects

Common side effects of trametinib:

  • High blood sugar
  • Higher liver enzymes in the blood
  • Fever
  • Tiredness
  • Rash
  • Nausea
  • Headache
  • Chills
  • Diarrhea
  • Vomiting
  • Dry skin
  • Lower appetite
  • Bleeding
  • Cough
  • Muscle or joint pain
  • Swelling in legs
  • Constipation
  • Stomach pain
  • High blood pressure
  • Trouble breathing
trametinib Serious Side Effects

trametinib Serious Side Effects

Serious side effects are rare with trametinib. Contact your healthcare provider immediately if you experience any of the following.

  • Bleeding: nosebleed, blood in stool, sudden and severe headache
  • Serious gut problems: sudden stomach pain, fever, blood in stool
  • Blood clots: swelling or warm, red skin in one arm or one leg; sudden trouble breathing; chest pain
  • Serious eye problems: sudden and severe eye pain, sudden vision loss
  • Serious lung problems: sudden cough, fever, trouble breathing, tightness in chest
  • Serious skin reactions: painful blisters, skin wounds, peeling skin, fever, muscle aches
  • Serious blood problems: fever, severe tiredness, trouble breathing
Effects of other drugs, drug classes and over-the-counter products on trametinib

Effects of other drugs, drug classes and over-the-counter products on trametinib

The following medications may interact with trametinib:

  • trametinib is indicated for use in combination with dabrafenib. Refer to the dabrafenib prescribing information
  • for additional risk information that applies to combination use treatment
Who makes trametinib?

Who makes trametinib?

Various FDA-approved generic manufacturers

Is trametinib safe in pregnancy?

Is trametinib safe in pregnancy?

trametinib can harm your unborn baby.
Females who are able to become pregnant: Your healthcare provider will do a test to see if you are pregnant before starting treatment with trametinib. You should use effective birth control (contraception) during treatment with trametinib and for 4 months after your last dose of trametinib. Talk to your healthcare provider about birth control methods that may be right for you during this time. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with trametinib.

Males (including those who have had a vasectomy) with a female partner who is able to become pregnant: Use condoms during sexual intercourse during treatment with trametinib and for at least 4 months after your last dose of trametinib.


What to do if you missed your trametinib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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