trametinib
Used for Cancer
NowPatient can significantly lower the cost* of your prescription medication by providing free access to drug coupons, savings cards, patient assistance programs and other out of pocket discount programs. Whether you’re insured, uninsured, or underinsured, we empower you with transparency and cost-saving tools to make your trametinib more affordable.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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trametinib key facts
What dosages is trametinib available in?
trametinib is available as a 0.5 mg and 2 mg oral tablet and a 4.7 mg oral solution.
What is trametinib used for?
trametinib is a MEK inhibitor and is used for the following:
- Melanoma with certain BRAF mutations
- Melanoma that has spread (metastatic) or can’t be removed by surgery, used by itself or with Tafinlar (dabrafenib)
- Advanced melanoma, given after surgery and used with Tafinlar (dabrafenib)
- Metastatic non-small cell lung cancer (NSCLC) with a certain BRAF mutation, used with Tafinlar (dabrafenib)
- Metastatic anaplastic thyroid cancer (ATC) with a certain BRAF mutation, used with Tafinlar (dabrafenib)
- Solid tumors with a certain BRAF mutation that have spread or can’t be removed by surgery, used with
- Tafinlar (dabrafenib)
- Low-grade glioma (LGG) with a certain BRAF mutation, used with Tafinlar (dabrafenib)
How does trametinib work?
trametinib is a kinase inhibitor known as a MEK inhibitor. The MEK protein is part of a whole chain of proteins that work to help cells grow. By blocking MEK, this medication helps stop tumor growth. trametinib is taken together with an anticancer medication called Tafinlar (dabrafenib) that specifically targets another protein in this chain (the BRAF protein). When the BRAF protein is mutated, the cancer can grow uncontrollably and spread more quickly. By blocking two different proteins in this pathway, trametinib and Tafinlar (dabrafenib) work together to stop the growth and spread of cancer better.
How do I take trametinib?
trametinib is dosed as follows:
- Adults: The typical dose is 2 mg by mouth once a day
- Children: The dose depends on your child’s body weight. The typical dose ranges from 0.3 mg to 2 mg by mouth once a day
Is it safe for me to take trametinib?
trametinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
trametinib Common Side Effects
Common side effects of trametinib:
- High blood sugar
- Higher liver enzymes in the blood
- Fever
- Tiredness
- Rash
- Nausea
- Headache
- Chills
- Diarrhea
- Vomiting
- Dry skin
- Lower appetite
- Bleeding
- Cough
- Muscle or joint pain
- Swelling in legs
- Constipation
- Stomach pain
- High blood pressure
- Trouble breathing
trametinib Serious Side Effects
Serious side effects are rare with trametinib. Contact your healthcare provider immediately if you experience any of the following.
- Bleeding: nosebleed, blood in stool, sudden and severe headache
- Serious gut problems: sudden stomach pain, fever, blood in stool
- Blood clots: swelling or warm, red skin in one arm or one leg; sudden trouble breathing; chest pain
- Serious eye problems: sudden and severe eye pain, sudden vision loss
- Serious lung problems: sudden cough, fever, trouble breathing, tightness in chest
- Serious skin reactions: painful blisters, skin wounds, peeling skin, fever, muscle aches
- Serious blood problems: fever, severe tiredness, trouble breathing
Effects of other drugs, drug classes and over-the-counter products on trametinib
The following medications may interact with trametinib:
- trametinib is indicated for use in combination with dabrafenib. Refer to the dabrafenib prescribing information
- for additional risk information that applies to combination use treatment
Who makes trametinib?
Various FDA-approved generic manufacturers
Is trametinib safe in pregnancy?
trametinib can harm your unborn baby.
Females who are able to become pregnant: Your healthcare provider will do a test to see if you are pregnant before starting treatment with trametinib. You should use effective birth control (contraception) during treatment with trametinib and for 4 months after your last dose of trametinib. Talk to your healthcare provider about birth control methods that may be right for you during this time. Tell your healthcare provider right away if you become pregnant or think you might be pregnant during treatment with trametinib.
Males (including those who have had a vasectomy) with a female partner who is able to become pregnant: Use condoms during sexual intercourse during treatment with trametinib and for at least 4 months after your last dose of trametinib.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my trametinib prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your trametinib prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient trametinib savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient trametinib savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for trametinib | Canadian Prescription Savings* for trametinib | trametinib Drug Coupon* | trametinib Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of trametinib?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for trametinib | Canadian Prescription Savings* for trametinib | trametinib Drug Coupon* | trametinib Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the trametinib savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the trametinib drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for trametinib, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the trametinib prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, trametinib is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed trametinib for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the trametinib prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the trametinib prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for trametinib
If you are having trouble paying for your trametinib medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for trametinib you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- trametinib is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers trametinib
- If trametinib is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for trametinib
If you are having trouble paying for your trametinib medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for trametinib you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers trametinib
- If trametinib is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for trametinib
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your trametinib treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for trametinib you will need to meet the following criteria:
- You must be currently insured and have coverage for trametinib
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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