temozolomide
Used for Cancer
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Manufactured by various FDA-approved generic manufacturers.
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temozolomide Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is temozolomide available in?
temozolomide is available as a 5 mg, 20 mg, 100 mg, 140 mg, 180 mg, and 250 mg oral capsule.
What is temozolomide used for?
temozolomide is an alkylating drug indicated for the treatment of adults
with:
- Newly diagnosed glioblastoma concomitantly with radiotherapy and then as maintenance treatment
- Anaplastic astrocytoma
Adjuvant treatment of adults with newly diagnosed anaplastic astrocytoma. - Treatment of adults with refractory anaplastic astrocytoma
How does temozolomide work?
temozolomide is an alkylating agent. This means it binds to the DNA in cells and interferes specifically with cell growth and division – preventing the tumour from growing.
How do I take temozolomide?
The amount of temozolomide that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
Is it safe for me to take temozolomide?
temozolomide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a history of serious hypersensitivity to temozolomide or any other ingredients in temozolomide and dacarbazine.
temozolomide Common Side Effects
Common side effects of temozolomide:
- Headache
- Seizure
- Constipation, nausea, vomiting, diarrhea, belly pain, loss of appetite
- Trouble with memory
- Difficulty sleeping
- Muscle weakness, paralysis, difficulty walking
- Dizziness
- Tiredness
- Hair loss
temozolomide Serious Side Effects
Serious side effects are rare with temozolomide. Contact your healthcare provider immediately if you experience any of the following.
- Damage to the lungs which may cause shortness of breath or cough to the bone marrow (irreversible) which may cause infection, bleeding, may require blood transfusions
- Liver damage which may cause yellowing of eyes and skin, swelling
- A new cancer including leukemia resulting from treatment
- Allergic reaction which may cause rash, low blood pressure, wheezing, shortness of breath, swelling of the face or throat
Effects of other drugs, drug classes and over-the-counter products on temozolomide
- There are no major drug interactions listed for temozolomide. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking
Who makes temozolomide?
Various FDA-approved generic manufacturers
Is temozolomide safe in pregnancy?
Based on findings from animal studies and its mechanism of action, temozolomide can cause fetal harm when administered to a pregnant woman. If you can become pregnant, use effective contraception during treatment with temozolomide and for 6 months after the last dose. Because of potential risk of genotoxic effects on sperm, advise male patients with female partners of reproductive potential to use condoms during treatment with temozolomide and for 3 months after the last dose. Advise male patients not to donate semen during treatment with
temozolomide and for 3 months after the last dose.
What to do if you missed your temozolomide dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effectsDrug Savings Tips
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
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Is temozolomide FDA approved for glioblastoma?
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