Used for Cancer

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Manufactured by Janssen Pharmaceuticals

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TECVAYLI Uses, Side Effects, Interactions, Warnings & Dosing



TECVAYLI is the brand name for teclistamab-cqyv and is available as a subcutaneous injection.

What dosages is TECVAYLI available in?

What dosages is TECVAYLI available in?

TECVAYLI is available as a subcutaneous injection that contains 30 mg/3 mL (10 mg/mL) or 153 mg/1.7 mL (90 mg/mL.

What is TECVAYLI used for?

What is TECVAYLI used for?

  • TECVAYLI is a monoclonal antibody that is used to treat advanced multiple myeloma in adults who’ve already tried at least four other therapies
How does TECVAYLI work?

How does TECVAYLI work?

TECVAYLI is a monoclonal antibody. More specifically, it’s called a bispecific T-cell engager, or BiTE therapy. This medication works by binding to 2 targets: it grabs onto both the multiple myeloma cancer cells and immune cells in your body called T-cells. By bringing these cells together, TECVAYLI makes it easier for the T cells to attack the cancer cells. In addition, when TECVAYLI binds to both cells, the multiple myeloma cancer cells can’t grow or spread as well.

How do I take TECVAYLI?

How do I take TECVAYLI?

  • Your provider will determine your dose of TECVAYLI based on your body weight. This medication is injected under the skin by a healthcare provider, typically in a hospital or clinic setting
  • Starting dose (“step-up” dosing): During your first week of treatment, your provider will raise your dose over the course of a week
  • Day 1 dose: 0.06 mg/kg injected once
  • Day 4 dose: 0.3 mg/kg injected once
  • Day 7 dose: 1.5 mg/kg injected once
  • Maintenance dose: Starting a week after the last dose, your provider will give you 1.5 mg/kg injected under the skin once a week
Is it safe for me to take TECVAYLI?

Is it safe for me to take TECVAYLI?

TECVAYLI is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

TECVAYLI Common Side Effects

TECVAYLI Common Side Effects

Common side effects of TECVAYLI:

  • Lower blood cell counts
  • Fever
  • Cytokine release syndrome
  • Low protein (albumin) levels in blood
  • Muscle pain
  • Higher liver enzymes in blood
  • Electrolyte changes in blood
  • Skin reaction around injection site
  • Tiredness
  • Respiratory infections
  • Nausea
  • Headache
  • Diarrhea
TECVAYLI Serious Side Effects

TECVAYLI Serious Side Effects

Serious side effects are rare with TECVAYLI. Contact your healthcare provider immediately if you experience any of the following.

  • Cytokine release syndrome: Fever, trouble breathing, chills, low blood pressure, changes in heart rhythm, headache
  • Serious nervous system problems: headache, confusion,
  • difficulty speaking, difficulty writing, seizures
    Serious liver problems: yellow skin, yellow eyes, swelling in the belly
  • Serious infection: fever, cough, weakness, tiredness, body aches, chills, painful rash, blisters, stomach pain
Effects of other drugs, drug classes and over-the-counter products on TECVAYLI

Effects of other drugs, drug classes and over-the-counter products on TECVAYLI

The following medications may interact with TECVAYLI:

  • TECVAYLI causes release of cytokines that may suppress activity of cytochrome P450 (CYP) enzymes, resulting in increased exposure of CYP substrates. The highest risk of drug-drug interaction is expected to occur from initiation of TECVAYLI step-up dosing schedule up to 7 days after the first treatment dose and during and after CRS. Monitor for toxicity or concentrations of drugs that are CYP substrates where minimal concentration changes may lead to serious adverse reactions. Adjust the dose of the concomitant CYP substrate drug as needed
Who makes TECVAYLI?

Who makes TECVAYLI?

Janssen Pharmaceuticals

Is TECVAYLI safe in pregnancy?

Is TECVAYLI safe in pregnancy?

IBased on its mechanism of action, TECVAYLI may cause fetal harm when administered to a pregnant woman. If you can become pregnant you should use effective contraception during treatment with TECVAYLI and for 5 months after the last dose.


What to do if you missed your TECVAYLI dose

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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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