TASIGNA

Used for Cancer

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Manufactured by Novartis Pharmaceuticals

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TASIGNA Uses, Side Effects, Interactions, Warnings & Dosing

What is TASIGNA?

What is TASIGNA?

TASIGNA is the brand name for nilotinib and is available as an oral capsule.

What dosages is TASIGNA available in?

What dosages is TASIGNA available in?

TASIGNA is available as a 50 mg, 150 mg, and 200 mg oral capsule.

What is TASIGNA used for?

What is TASIGNA used for?

TASIGNA is a tyrosine kinase inhibitor that is used to treat Philadelphia chromosome-positive chronic myelogenous leukemia (Ph+ CML).

How does TASIGNA work?

How does TASIGNA work?

TASIGNA is a tyrosine kinase inhibitor (TKI). It blocks a certain protein in your body called BCR-ABL tyrosine kinase. This protein is only found on cancer cells like those of CML and not on normal, healthy cells. It causes the cancer cells to grow and multiply. By blocking this protein, it kills cancer cells and stops their spread.

How do I take TASIGNA?

How do I take TASIGNA?

TASIGNA is dosed as follows:

Adults:

  • For newly-diagnosed Ph+ CML, the typical starting dose is 300 mg by mouth twice a day (about 12 hours apart)
  • If you’ve taken a similar medication before that didn’t work to treat your cancer, the typical dose of Tasigna (nilotinib) is 400 mg by mouth twice a day

Children:

  • Dosing will depend on the child’s body surface area (BSA), which takes into account their height and weight. Dosage starts from 50 mg to 400 mg by mouth twice a day (about 12 hours apart)
  • Your dose might differ if you’re taking certain medications that interact with TTASIGNA, you’ve had your stomach surgically removed, or if you have liver problems
Is it safe for me to take TASIGNA?

Is it safe for me to take TASIGNA?

TASIGNA is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have hypokalemia, hypomagnesemia, or long QT syndrome.

TASIGNA Common Side Effects

TASIGNA Common Side Effects

Common side effects of TASIGNA:

  • Rash
  • Nausea
  • Headache
  • Tiredness
  • Itchy skin
  • Vomiting
  • Diarrhea
  • Fever
  • Cold-like symptoms
  • Cough
  • Sweating at night
  • Constipation
  • Joint pain
  • Pain in arms or legs
TASIGNA Serious Side Effects

TASIGNA Serious Side Effects

Serious side effects are rare with TASIGNA. Contact your healthcare provider immediately if you experience any of the following.

  • Irregular heartbeat: fast heartbeat, chest discomfort, dizziness, fainting
  • Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, blood in the urine, throwing up blood, bloody or black and tarry stool
  • Heart problems: chest pain, racing heart, shortness of breath, swelling of legs or feet, sudden weight gain, fatigue
  • Stroke: weakness on one side of body, severe headache, problems with vision or speech, confusion
  • Abnormal electrolyte levels and kidney problems: racing heart, muscle cramps or spasms, numbness, nausea, vomiting, dark urine, not urinating as much as usual, pain on either side of the lower back
Effects of other drugs, drug classes and over-the-counter products on TASIGNA

Effects of other drugs, drug classes and over-the-counter products on TASIGNA

The following medications may interact with TASIGNA:

  • Strong CYP3A Inhibitors: Avoid concomitant use with Tasigna, or reduce
  • Tasigna dose if coadministration cannot be avoided.
  • Strong CYP3A Inducers: Avoid concomitant use with Tasigna
  • Proton Pump Inhibitors: Use short-acting antacids or H2 blockers as an alternative to proton pump inhibitors
Who makes TASIGNA?

Who makes TASIGNA?

Novartis Pharmaceuticals

Is TASIGNA safe in pregnancy?

Is TASIGNA safe in pregnancy?

TASIGNA can harm your unborn baby. Tell your healthcare provider right away if you are pregnant, or if you become pregnant during treatment with Tasigna.

In females who are able to become pregnant:

  • Your healthcare provider should do a pregnancy test before you start treatment with Tasigna.
  • Use effective birth control (contraception) during treatment with Tasigna and for 14 days after the last dose.
What is the generic name for TASIGNA?

What is the generic name for TASIGNA?

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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