Used for Cancer

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Manufactured by various FDA-approved generic manufacturers.

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

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sunitinib Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is sunitinib available in?

What dosages is sunitinib available in?

sunitinib is available as 12.5 mg, 25 mg, 37.5 mg, or 50 mg oral capsule

What is sunitinib used for?

What is sunitinib used for?

sunitinib is a kinase inhibitor indicated for:

  • Treatment of adult patients with gastrointestinal stromal tumor (GIST) after disease progression on or intolerance to imatinib mesylate
  • Treatment of adult patients with advanced renal cell carcinoma (RCC)
  • Adjuvant treatment of adult patients at high risk of recurrent RCC following nephrectomy
  • Treatment of progressive, well-differentiated pancreatic neuroendocrine tumors (pNET) in adult patients with unresectable locally advanced or metastatic disease
How does sunitinib work?

How does sunitinib work?

sunitinib targets proteins in cancer cells and stops the cancer cells from growing.

How do I take sunitinib?

How do I take sunitinib?

sunitinib is dosed as follows:

GIST and Advanced RCC:

  • The recommended dosage is 50 mg orally once daily for the first 4 weeks of each 6-week cycle (Schedule 4/2)

Adjuvant Treatment of RCC:

  • The recommended dosage is 50 mg orally once daily for the first 4 weeks of a 6-week cycle (Schedule 4/2) for a maximum of 9 cycles


  • The recommended dosage is 37.5 mg orally once daily
Is it safe for me to take sunitinib?

Is it safe for me to take sunitinib?

sunitinib is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

sunitinib Common Side Effects

sunitinib Common Side Effects

Common side effects of sunitinib:

  • Tiredness
  • Weakness
  • Diarrhea
  • Pain, swelling or sores inside of your mouth
  • Nausea
  • Loss of appetite
  • Indigestion
  • Vomiting
  • Stomach-area (abdominal) pain
  • Blisters or rash on the palms of your hands and soles of your feet
  • High blood pressure
  • Taste changes
  • Low platelet counts
sunitinib Serious Side Effects

sunitinib Serious Side Effects

Serious side effects are rare with sunitinib. Contact your doctor if you experience any of the following.

  • Heart problems
  • Abnormal heart rhythm changes
  • Bleeding problems
  • Serious stomach and intestinal problems
  • Tumor lysis syndrome (TLS)
  • Abnormal changes in the brain
  • Blood clots
  • Serious skin and mouth reactions
  • Thyroid problems
  • Jawbone problems (osteonecrosis)
    Wound healing problems
Effects of other drugs, drug classes and over-the-counter products on sunitinib

Effects of other drugs, drug classes and over-the-counter products on sunitinib

The following medications may interact with sunitinib:

  • CYP3A4 Inhibitors: Consider dose reduction of sunitinib when administered with strong CYP3A4 inhibitors
  • CYP3A4 Inducers: Consider dose increase of sunitinib when administered with strong CYP3A4 inducers
Who makes sunitinib?

Who makes sunitinib?

Various FDA-approved generic manufacturers

Is sunitinib safe in pregnancy?

Is sunitinib safe in pregnancy?

sunitinib can harm your unborn baby.

Females who are able to become pregnant:

  • Your healthcare provider should do a pregnancy test before you start treatment with sunitinib
  • You should use effective birth control (contraception) during treatment and for at least 4 weeks after your last dose of sunitinib
  • Tell your healthcare provider right away if you become pregnant or think you are pregnant during treatment with sunitinib
  • Males with female partners who are able to become pregnant should use effective birth control (contraception) during treatment and for 7 weeks after your last dose of sunitinib
  • sunitinib may cause fertility problems in males and females. Tell your healthcare provider if this is a concern for you

What to do if you missed your sunitinib dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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