Used for Migraines

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Manufactured by various FDA-approved generic manufacturers.

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Navin Khosla NowPatientGreen tick
Updated on 24 Apr 2024

sumatriptan Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is sumatriptan available in?

What dosages is sumatriptan available in?

sumatriptan is available as a 25 mg, 50 mg, and 100 mg oral tablet.

What is sumatriptan used for?

What is sumatriptan used for?

sumatriptan is a triptan and is used to treat migraine attacks with or without aura in adults.

How does sumatriptan work?

How does sumatriptan work?

sumatriptan is a triptan. It works by attaching to and turning on serotonin receptors in the blood vessels and nerves in your brain. This causes the blood vessels to tighten as well as lower the release of proteins that cause inflammation and pain. This is thought to help relieve migraines.

How do I take sumatriptan?

How do I take sumatriptan?

sumatriptan is typically dosed as 25 mg, 50 mg, or 100 mg by mouth for one single dose as soon as you get a migraine. If your migraine doesn’t go away or comes back after some improvement, you can take a second dose at least 2 hours after your first dose. Don’t take more than 200 mg in a 24-hour period. Your dose might differ if you have liver problems.

Is it safe for me to take sumatriptan?

Is it safe for me to take sumatriptan?

sumatriptan is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a history of coronary artery disease or coronary artery vasospasm, Wolff-Parkinson-White syndrome or other cardiac accessory conduction pathway disorders, a history of stroke, transient ischemic attack, or hemiplegic or basilar migraine, peripheral vascular disease, ischemic bowel disease, uncontrolled hypertension, or recent (within 24 hours) use of another 5-HT1 agonist (e.g., another  triptan) or of an ergotamine-containing medication.

sumatriptan Common Side Effects

sumatriptan Common Side Effects

Common side effects of sumatriptan include:

  • Tingling or numbness of fingers or toes
  • Feeling too warm or too cold
  • Fatigue
sumatriptan Serious Side Effects

sumatriptan Serious Side Effects

Serious side effects are rare with sumatriptan. Contact your healthcare provider immediately if you experience any of the following:

  • Heart problems: heart attack, dangerously high blood pressure, severe headache, chest pain, trouble breathing, irregular heartbeat
  • Stroke: sudden weakness on one side of your body, headache, changes in your speech or vision, confusion
  • Serotonin syndrome: fast heart rate, dizziness, sweating, flushing, tremor (shakiness), muscle stiffness or twitching, uncoordinated movement, hallucinations
  • Allergic reaction: rash or hives, swelling of face or throat, trouble breathing
  • Narrowing of blood vessels in the body: bloody diarrhea; severe stomach pain; partial or permanent blindness; tightness, weakness, numbness of legs or feet
Effects of other drugs, drug classes and over-the-counter products on sumatriptan

Effects of other drugs, drug classes and over-the-counter products on sumatriptan

The following medications may interact with sumatriptan:

  • Ergot-Containing Drugs: Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and sumatriptan tablets within 24 hours of each other is contraindicated
  • Monoamine Oxidase-A Inhibitors: MAO-A inhibitors increase systemic exposure by 7-fold. Therefore, the use of sumatriptan tablets in patients receiving MAO-A inhibitors is contraindicated
  • Other 5-HT1 Agonists: Because their vasospastic effects may be additive, coadministration of sumatriptan tablets andother 5-HT1 agonists (e.g., triptans) within 24 hours of each other is contraindicated
  • Selective Serotonin Reuptake Inhibitors/Serotonin Norepinephrine Reuptake Inhibitors: Cases of serotonin syndrome have been reported during coadministration of triptans and SSRIs
  • SNRIs, TCAs, and MAO inhibitors
Who makes sumatriptan?

Who makes sumatriptan?

Various FDA-approved generic manufacturers

Is sumatriptan safe in pregnancy?

Is sumatriptan safe in pregnancy?

sumatriptan may cause harm to your unborn baby based on animal studies. You should talk to your healthcare provider before taking this medication if you are pregnant.


What to do if you missed your sumatriptan dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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