Sulfamethoxazole Generic

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Sulfamethoxazole / Trimethoprim
    Generic for Bactrim
    30 tablets $4.5 USD
    Save $13.20
  3. Sulfamethoxazole / Trimethoprim
    Generic for Bactrim
    30 tablets $5.1 USD
    Save $12.60
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Do you need a prescription for sulfamethoxazole?

Yes, sulfamethoxazole is only available with a valid physician Rx.

How much is sulfamethoxazole without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase sulfamethoxazole, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for sulfamethoxazole in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a sulfamethoxazole savings card?

Yes. Save up to 90% on your sulfamethoxazole with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a sulfamethoxazole coupon provider in the US?

No. Now Patient does not provide sulfamethoxazole coupons or FREE sulfamethoxazole samples.

Do you accept commercial, Medicare or Medicaid coverage for sulfamethoxazole in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much sulfamethoxazole?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using sulfamethoxazole. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much sulfamethoxazole. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic sulfamethoxazole?

Generic sulfamethoxazole refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of sulfamethoxazole

Sulfamethoxazole is approved by the U.S. Food and Drug Administration (FDA) for the treatment of various bacterial infections.

Active ingredient of sulfamethoxazole

The active ingredient of sulfamethoxazole is sulfamethoxazole.

US brand name of sulfamethoxazole and manufacturer

Sulfamethoxazole is available in the US under various brand names, including Bactrim, Bactrim DS, Septra, and Sulfatrim. The manufacturer may vary depending on the brand name.

UK brand name of sulfamethoxazole and manufacturer

In the UK, sulfamethoxazole is only available in conjunction with trimethoprim, under the name co-trimoxazole.

Prescription requirement for sulfamethoxazole

A prescription (Rx) is required for sulfamethoxazole in the US.

Availability of sulfamethoxazole in the UK with NHS prescription

Sulfamethoxazole is not available in the UK.

Conditions treated by sulfamethoxazole

Sulfamethoxazole (SMX) is used for the treatment of various bacterial infections, including urinary tract infections, respiratory tract infections, and skin infections. Sulfamethoxazole may be used in  combination with trimethoprim to treat otitis media, bronchitis, shigellosis, and traveler’s diarrhea. Sulfamethoxazole may also be used to prevent or treat Pneumocystis carinii pneumonia (PCP) or Pneumocystis jiroveci pneumonia, a very serious kind of pneumonia.

How does sulfamethoxazole work?

Sulfamethoxazole is a sulfonamide antibiotic that works by inhibiting the growth and replication of bacteria. It achieves this by blocking the synthesis of essential components required for bacterial survival.

Forms of sulfamethoxazole available

Sulfamethoxazole is available in the form of oral tablets and oral suspension.

Dosage of sulfamethoxazole

The dosage of sulfamethoxazole may vary depending on the individual’s specific condition, age, and response to treatment. It is important to follow the recommended dosage instructions provided by the healthcare provider.

Directions for sulfamethoxazole use

Sulfamethoxazole should be taken exactly as directed by the healthcare provider. The tablets or suspension are usually taken orally, with or without food. It is important to complete the full course of treatment as prescribed, even if symptoms improve.

Warnings and precautions for sulfamethoxazole

  • Sulfamethoxazole may have certain risks and potential side effects. It is important to discuss these with a healthcare provider before starting the medication
  • Sulfamethoxazole may increase the risk of severe allergic reactions, including skin rash and Stevens-Johnson syndrome
  • Tell your doctor if you have kidney disease, liver disease, anemia due to folate deficiency, porphyria, history of blood disorders caused by sulfa medications, vitamin deficiency (folic acid or folate), asthma, G6PD (glucose-6-phosphate-dehydrogenase) deficiency, an underactive thyroid, or high potassium serum levels
  • This medication passes into breast milk. Tell your doctor if you are breast-feeding

Use of sulfamethoxazole if pregnant or planning pregnancy

The use of sulfamethoxazole during pregnancy should be discussed with a healthcare provider. It may be used during pregnancy if the potential benefits outweigh the risks.

Possible side effects of sulfamethoxazole

Common side effects of sulfamethoxazole may include nausea, vomiting, diarrhea, loss of appetite, and skin rash. Serious side effects are possible but less common. Promptly report any concerning symptoms to a healthcare provider. Get medical help right away if you have any serious side effects such as an allergic reaction. Symptoms include hives, trouble breathing, shortness of breath, sore throat, chest pain, swelling of the face, tongue or throat, skin rash, and severe skin reactions. Promptly report any adverse effects to a healthcare professional for medical advice.

Interactions with other drugs

Sulfamethoxazole may interact with certain medications, including amantadine, angiotensin converting enzyme inhibitors, anticoagulants such as warfarin, dofetilide, cyclosporine, digoxin, diuretics, phenytoin, methotrexate, and pyrimethamine. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medication, salt substitutes, supplements, and vitamins you are taking to avoid potential adverse effects and drug interactions.

Similar drugs to sulfamethoxazole

Other sulfonamide antibiotics used for the treatment of bacterial infections include trimethoprim-sulfamethoxazole (co-trimoxazole), sulfadiazine, and sulfisoxazole.


Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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