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Siliq is the brand name for brodalumab and is available as a subcutaneous injection.

Siliq is available as a 210 mg/1.5 mL solution in a single-dose prefilled syringe.

Siliq is a monoclonal antibody and is used to treat moderate to severe plaque psoriasis (where people are candidates for systemic therapy or phototherapy, but haven’t responded to other treatments).

Siliq is a monoclonal antibody that binds to receptors (proteins) in your body to lower the number of cells that cause inflammation.

Siliq is dosed as follows:

• The typical dose of Siliq starts out with three starter doses at weeks 0, 1, and 2, and then you’ll take it every 2 weeks. Siliq comes in a single-dose prefilled syringe that contains 210 mg (1.5 mL) of medication
• Week 0 (beginning of treatment): Inject 210 mg under the skin once
• Week 1: Inject 210 mg under the skin once
• Week 2: Inject 210 mg under the skin once
• Week 4 and on: Inject 210 mg under the skin once every 2 weeks

Siliq is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have Crohn’s disease.

Common side effects of Siliq:

• Joint pain
• Headache
• Feeling low energy
• Diarrhea
• Sore throat
• Nausea
• Muscle pain
• Injection site reactions

Serious side effects are rare with Siliq. Contact your healthcare provider immediately if you experience any of the following.

• Serious infections: fever, difficulty breathing, cough that won’t go away, night sweats, confusion, feeling very tired, diarrhea, chills
• Suicidal thoughts and behaviors

The following medications may interact with Siliq:

• Live Vaccinations: Avoid use of live vaccines in patients treated with Siliq
• CYP450 Substrates: The formation of CYP450 enzymes can be altered by increased levels of certain cytokines (e.g., IL-1, IL-6, IL-10, TNFα, IFN) during chronic inflammation. Treatment with Siliq may modulate serum levels of some cytokines
• Therefore, upon initiation or discontinuation of Siliq in patients who are receiving concomitant drugs which are CYP450 substrates, particularly those with a narrow therapeutic index, consider monitoring for effect (e.g., for warfarin) or drug concentration (e.g., for cyclosporine) and consider dosage modification of the CYP450 substrate

Valeant Pharmaceuticals

It is not known if Siliq will harm your unborn baby. Siliq should be given to a pregnant woman only if clearly needed.

• Brodalumab