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Seroquel is the brand name for quetiapine and is available as an oral tablet.

Seroquel is available as a 25 mg, 50 mg, 100 mg, 200 mg, 300 mg, and 400 mg oral tablet.

Seroquel is an atypical antipsychotic and is used to treat the following:

• Schizophrenia in adults and children age 13 years and older
• Bipolar disorder in adults and children age 10 years and older
• Add-on to antidepressants for depression (extended-release only)

Seroquel is an atypical antipsychotic. It’s not completely known how Seroquel works, but it’s thought to work by balancing out the levels of chemicals (dopamine and serotonin) in your brain to help control your thoughts, mood, and behaviors.

Seroquel is dosed as follows:

• Schizophrenia (adults and children): The typical starting dose is to take 25 mg by mouth twice daily. Your provider will raise your dose slowly over time. The typical maintenance dose ranges from 150 mg to 800 mg daily, divided into smaller doses and taken twice to three times throughout the day
• Bipolar I disorder (adults and children): The typical starting dose ranges from 25 mg to 50 mg by mouth twice daily, depending on age and whether or not you’re taking other medications for bipolar disorder. Your provider will raise your dose slowly over time. The typical maintenance dose ranges from 400 mg to 800 mg daily, divided into smaller doses and taken twice to three times throughout the day

Seroquel is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Seroquel:

• Headache
• Agitation
• Sleepiness
• Dizziness
• Dry mouth
• Constipation
• Pain

Serious side effects are rare with Seroquel. Contact your healthcare provider immediately if you experience any of the following.

• Seizures
• Suicidal thoughts or actions
• Neuroleptic malignant syndrome: fever, sweating, stiff muscles, confusion, not aware of your surroundings, fast or irregular heartbeat
• Abnormal heart rhythm (QT prolongation): chest pounding, short of breath, chest pain, feeling faint or lightheaded
• Dangerously high blood sugar: frequently thirsty, needing to urinate often, tiredness, nausea, vomiting, difficulty breathing, having fruity breath, having dry mouth
• Serious infections: fever, headache, chills, body aches, cough, weakness
• Severe allergic reactions: swelling of the face, tongue, or throat, difficulty breathing

The following medications may interact with Seroquel:

• P450 3A Inhibitors: May decrease the clearance of quetiapine. Lower doses of quetiapine may be required.
• Hepatic Enzyme Inducers: May increase the clearance of quetiapine
• Higher doses of quetiapine may be required with phenytoin or other inducers
• Centrally Acting Drugs: Caution should be used when quetiapine is used in combination with other CNS acting drugs
• Antihypertensive Agents: Quetiapine may add to the hypotensive effects of these agents
• Levodopa and Dopamine Agents: Quetiapine may antagonize the effect of these drugs

AstraZeneca

There are no adequate and well-controlled studies in pregnant women and Seroquel should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

• Quetiapine