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Updated on 24 Apr 2024

saxagliptin/dapagliflozin Uses, Side Effects, Interactions, Warnings & Dosing

What dosages is saxagliptin/dapagliflozin available in?

What dosages is saxagliptin/dapagliflozin available in?

saxagliptin/dapagliflozin is available as an oral tablet that contains 5 mg dapagliflozin/5 mg saxagliptin or 10 mg dapagliflozin/5 mg saxagliptin.

What is saxagliptin/dapagliflozin used for?

What is saxagliptin/dapagliflozin used for?

saxagliptin/dapagliflozin is a SGLT2 inhibitor / DPP-4 inhibitor that is used to treat type 2 diabetes.

How does saxagliptin/dapagliflozin work?

How does saxagliptin/dapagliflozin work?

saxagliptin/dapagliflozin is a combination of two medications.

  • Dapagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It works in the kidneys to prevent the absorption of sugar back into your body. It lowers blood sugar by causing your body to get rid of excess sugar through your urine
  • Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It works by blocking DPP-4, a protein that breaks down certain hormones that normally tell your body to make more insulin and produce less sugar. In doing so, saxagliptin helps lower your blood sugar levels
How do I take saxagliptin/dapagliflozin?

How do I take saxagliptin/dapagliflozin?

The typical starting dose of saxagliptin/dapagliflozin is 5 mg/5 mg (dapagliflozin / saxagliptin) by mouth once daily in the morning. The maximum dose of saxagliptin/dapagliflozin is 10 mg/5 mg (dapagliflozin / saxagliptin) once daily in the morning.

Is it safe for me to take saxagliptin/dapagliflozin?

Is it safe for me to take saxagliptin/dapagliflozin?

saxagliptin/dapagliflozin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. saxagliptin/dapagliflozin is contraindicated in patients with:

  • History of a serious hypersensitivity reaction to dapagliflozin or to saxagliptin, such as anaphylaxis, angioedema, or exfoliative skin conditions
    Moderate to severe renal impairment (eGFR <45 mL/min/1.73 m2), end-stage renal disease (ESRD), or patients on dialysis
saxagliptin/dapagliflozin Common Side Effects

saxagliptin/dapagliflozin Common Side Effects

Common side effects of saxagliptin/dapagliflozin:

  • Sore throat, cough, and other symptoms of an upper respiratory tract infection
  • Pain or discomfort while urinating and other symptoms of an urinary tract infection
  • High cholesterol or fats in the blood
  • Headache
  • Diarrhea
saxagliptin/dapagliflozin Serious Side Effects

saxagliptin/dapagliflozin Serious Side Effects

Serious side effects are rare with saxagliptin/dapagliflozin. Contact your healthcare provider immediately if you experience any of the following.

  • Inflamed pancreas: upper stomach pain, fever, nausea, vomiting
  • Ketoacidosis (too much blood acid): trouble breathing, vomiting, belly pain, dry skin and mouth, feeling very tired, fruity-smelling breath
  • Sudden kidney problems: urinating less than usual, chest pain
  • Low blood pressure: dizziness, lightheadedness, confusion
  • Serious genital skin infection: pain, swelling, or redness in the genital area, fever, weakness
  • Severe skin or allergic reactions: rash, blisters, sores, trouble breathing, swelling
Effects of other drugs, drug classes and over-the-counter products on saxagliptin/dapagliflozin

Effects of other drugs, drug classes and over-the-counter products on saxagliptin/dapagliflozin

The following medications may interact with saxagliptin/dapagliflozin:

  • Strong CYP3A4/5 Inhibitors (e.g., Ketoconazole): Do not coadminister
  • saxagliptin/dapagliflozin with strong cytochrome P450 3A4/5 inhibitors
Who makes saxagliptin/dapagliflozin?

Who makes saxagliptin/dapagliflozin?

Various FDA-approved generic manufacturers

Is saxagliptin/dapagliflozin safe in pregnancy?

Is saxagliptin/dapagliflozin safe in pregnancy?

saxagliptin/dapagliflozin may harm your unborn baby. If you are pregnant or plan to become pregnant, talk to your healthcare provider about the best way to control your blood sugar.


What to do if you missed your saxagliptin/dapagliflozin dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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