Used for Schizophrenia

View SAPHRIS savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or SAPHRIS Patient Assistance Program.

Programs are suitable for individuals who want to buy SAPHRIS without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Allergan

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about SAPHRIS

What is SAPHRIS?

What is SAPHRIS?

SAPHRIS is the brand name for asenapine and is available as a sublingual tablet.

What dosages is SAPHRIS available in?

What dosages is SAPHRIS available in?

SAPHRIS is available as a 2.5 mg, 5 mg, and 10 mg sublingual tablet.

What is SAPHRIS used for?

What is SAPHRIS used for?

SAPHRIS is an atypical antipsychotic that is used to treat:

  • Schizophrenia
  • Bipolar I disorder
How does SAPHRIS work?

How does SAPHRIS work?

SAPHRIS is an atypical antipsychotic. It affects dopamine and serotonin activity in your brain, which can help regulate your thoughts, mood, and behaviors.

How do I take SAPHRIS?

How do I take SAPHRIS?

SAPHRIS is dosed as follows:


  • The usual dose is 5 mg under the tongue twice daily, with a maximum dose of 10 mg twice daily

Bipolar disorder

  • Adults: The typical dose is 5 mg to 10 mg under the tongue twice daily, with a maximum dose of 10 mg twice daily. Your dose will depend on if you’re taking other medications for bipolar
  • Children and teens aged 10 to 17 years: The typical dose is 2.5 mg to 10 mg under the tongue twice daily, with a maximum dose of 10 mg twice daily
Is it safe for me to take SAPHRIS?

Is it safe for me to take SAPHRIS?

SAPHRIS is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

  • Severe hepatic impairment (Child-Pugh C).
  • Known hypersensitivity to SAPHRIS or to any components in the formulation
SAPHRIS Common Side Effects

SAPHRIS Common Side Effects

Common side effects of SAPHRIS:

  • Trouble sleeping
  • Sleepiness
  • Movement problems
  • Restlessness (not being able to sit still)
  • Dizziness
  • Constipation
  • Vomiting
  • Mouth numbness
SAPHRIS Serious Side Effects

SAPHRIS Serious Side Effects

Serious side effects are rare with SAPHRIS. Contact your healthcare provider immediately if you experience any of the following.

  • Neuroleptic malignant syndrome: high fever, sweating, confusion, stiffness, changing blood pressure
  • Changes in heartbeat
  • Suicidal thoughts or actions
  • Seizures
Effects of other drugs, drug classes and over-the-counter products on SAPHRIS

Effects of other drugs, drug classes and over-the-counter products on SAPHRIS

The following medications may interact with SAPHRIS:

  • Antihypertensive Drugs: SAPHRIS may cause hypotension
  • Paroxetine (CYP2D6 substrate and inhibitor): Reduce paroxetine by half when used in combination with SAPHRIS
Who makes SAPHRIS?

Who makes SAPHRIS?


Is SAPHRIS safe in pregnancy?

Is SAPHRIS safe in pregnancy?

Neonates exposed to antipsychotic drugs such as SAPHRIS during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms. SAPHRIS should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to SAPHRIS during pregnancy. For more information contact the National Pregnancy Registry for Atypical Antipsychotics at 1-866-961­ 2388 or visit women’s health


What to do if you missed your SAPHRIS dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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