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MEDICAL INFORMATION
Saphris Key Facts
What is Saphris?
Saphris is the brand name for asenapine and is available as a sublingual tablet.
What dosages is Saphris available in?
Saphris is available as a 2.5 mg, 5 mg, and 10 mg sublingual tablet.
What is Saphris used for?
Saphris is an atypical antipsychotic that is used to treat:
- Schizophrenia
- Bipolar I disorder
How does Saphris work?
Saphris is an atypical antipsychotic. It affects dopamine and serotonin activity in your brain, which can help regulate your thoughts, mood, and behaviors.
How do I take Saphris?
Saphris is dosed as follows:
Schizophrenia
- The usual dose is 5 mg under the tongue twice daily, with a maximum dose of 10 mg twice daily
Bipolar disorder
- Adults: The typical dose is 5 mg to 10 mg under the tongue twice daily, with a maximum dose of 10 mg twice daily. Your dose will depend on if you’re taking other medications for bipolar
- Children and teens aged 10 to 17 years: The typical dose is 2.5 mg to 10 mg under the tongue twice daily, with a maximum dose of 10 mg twice daily
Is it safe for me to take Saphris?
Saphris is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:
- Severe hepatic impairment (Child-Pugh C).
- Known hypersensitivity to Saphris or to any components in the formulation
Saphris Common Side Effects
Common side effects of Saphris:
- Trouble sleeping
- Sleepiness
- Movement problems
- Restlessness (not being able to sit still)
- Dizziness
- Constipation
- Vomiting
- Mouth numbness
Saphris Serious Side Effects
Serious side effects are rare with Saphris. Contact your healthcare provider immediately if you experience any of the following.
- Neuroleptic malignant syndrome: high fever, sweating, confusion, stiffness, changing blood pressure
- Changes in heartbeat
- Suicidal thoughts or actions
- Seizures
Effects of other drugs, drug classes and over-the-counter products on Saphris
The following medications may interact with Saphris:
- Antihypertensive Drugs: Saphris may cause hypotension
- Paroxetine (CYP2D6 substrate and inhibitor): Reduce paroxetine by half when used in combination with Saphris
Who makes Saphris?
Allergan
Is Saphris safe in pregnancy?
Neonates exposed to antipsychotic drugs such as Saphris during the third trimester of pregnancy are at risk for extrapyramidal and/or withdrawal symptoms. Saphris should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Saphris during pregnancy. For more information contact the National Pregnancy Registry for Atypical Antipsychotics at 1-866-961 2388 or visit women’s health
What is the generic name for Saphris?
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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