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Saphnelo is the brand name for anifrolumab-fnia and is available as an IV infusion.

Saphnelo is available in a 300 mg/2 mL (150 mg/mL) in a single-dose vial.

Saphnelo is a biologic medication that is used as an add-on therapy for moderate-to-severe systemic lupus erythematosus (SLE).

Saphnelo is a biologic medication. It attaches to certain proteins in your immune system that play a role in SLE. By attaching to these proteins, it stops them from turning on and blocks inflammatory pathways in your body.

The typical dose of Saphnelo is 300 mg injected into the veins (IV) once every month. It’s given as an infusion over 30 minutes.

Saphnelo is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Saphnelo:

• Upper respiratory infection
• Bronchitis
• Infusion-related reactions (headache, dizziness, nausea)
• Herpes zoster infection (shingles)
• Cough

Serious side effects are rare with Saphnelo. Contact your healthcare provider immediately if you experience any of the following.

Severe infection: confusion, fever, difficulty breathing, weakness, cough, sweating, chills, stomach pain, diarrhea, burning sensation when you urinate
Serious allergic reaction (anaphylaxis): difficulty breathing, tightness in the throat, hives, itching, fast heartbeat, nausea, dizziness, lightheadedness, swelling in the face or tongue

There are no major drug interactions listed for Saphnelo. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

AstraZeneca

It is not known if Saphnelo will harm your unborn baby. Tell your healthcare provider
if you are pregnant, think you might be pregnant, or plan to become pregnant during your treatment with Saphnelo.
If you become pregnant while receiving Saphnelo, talk to your healthcare provider.
A pregnancy exposure registry monitors pregnancy outcomes in women exposed to Saphnelo. You can find out more
information about the registry by calling AstraZeneca at 1-877-693-9268.

• Anifrolumab-FNIA