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Sandostatin Lar Depot is the brand name for octreotide acetate and is available as an intramuscular injection.

Sandostatin Lar Depot is available as 10 mg per 6 mL, 20 mg per 6 mL, or 30 mg per 6 mL single-dose vials.

Sandostatin Lar Depot is a somatostatin analog and is used for the following: People who are currently taking and have responded well to short-acting octreotide (Sandostatin) can take Sandostatin Lar Depot (octreotide) for:

• Acromegaly
• Diarrhea and flushing linked to carcinoid tumors
• Diarrhea linked to vasoactive intestinal peptide tumors (VIPomas)

Sandostatin Lar Depot is a somatostatin analog. This means it acts like somatostatin, a hormone made by your body that blocks the release of many other hormones. It treats acromegaly, a condition where your body makes too much growth hormone (GH), by blocking your body from releasing too much GH. It also treats flushing and diarrhea caused by carcinoid tumors and diarrhea linked to VIPomas by blocking or lowering certain activities in your stomach, such as blood flow and gut movement.

You can only use Sandostatin Lar Depot if you’re currently using and have responded well to the appropriate dose of the short-acting octreotide (Sandostatin) for your condition, for at least 2 weeks.

• Sandostatin Lar Depot is given as an injection into the muscle (intramuscular or IM) of the buttocks by a healthcare provider
• Acromegaly: The typical starting dose is 20 mg IM monthly for 3 months. After this, your provider will adjust your monthly dose based on your growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels, as well as your symptoms. The typical maintenance dose ranges from 10 mg to 40 mg monthly.
• Carcinoid tumors and VIPomas: The typical starting dose is 20 mg IM monthly for 2 months. After this, your provider will adjust your monthly dose based on your symptoms. The typical maintenance dose ranges from 10 mg to 30 mg monthly

Your dose might differ if you have kidney or liver problems.

Sandostatin Lar Depot is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Sandostatin Lar Depot:

• Diarrhea
• Gallstones
• Stomach pain
• Passing gas
• Nausea
• Stomach pain
• Tiredness
• Headache
• Back pain
• Dizziness

Serious side effects are rare with Sandostatin Lar Depot. Contact your healthcare provider immediately if you experience any of the following.

• Dangerously low blood sugar: feeling faint, shaking, sweating, dizziness, fast heartbeat, nervousness, anxious, confused, irritable, feeling very hungry
• Dangerously high blood sugar: frequently thirsty, needing to urinate often, tiredness, nausea, vomiting, difficulty breathing, having fruity breath, having dry mouth
• Heart rhythm problems: Chest pounding, fluttering in the chest, difficulty breathing, chest pain, feeling faint or lightheaded
• Swelling of the gallbladder or pancreas: sudden pain in upper right portion of your stomach area, back pain between your shoulder blades, nausea, vomiting, fever, swelling in the belly, fast heartbeat, difficulty breathing

The following medications may interact with Sandostatin Lar Depot:

• The following drugs require monitoring and possible dose adjustment when used with Sandostatin Lar Depot: cyclosporine, insulin, oral hypoglycemic agents, beta-blockers, and bromocriptine.
• Lutetium Lu 177 Dotatate Injection: Discontinue SANDOSTATIN LAR
• DEPOT at least 4 weeks prior to each lutetium Lu 177 dotatate dose

Novartis Pharmaceuticals

It is not known if Sandostatin Lar Depot can harm your unborn baby. You and your healthcare provider should decide if you will use Sandostatin Lar Depot. Treatment with Sandostatin Lar Depot may result in unintended pregnancy.

• Octreotide Acetate