RiluzolePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  2. Riluzole
    Generic for Rilutek
    30 tablets $8.1 USD
    Save $388.80
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Do you need a prescription for riluzole?

Yes, riluzole is only available with a valid physician Rx.

How much is riluzole without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase riluzole, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for riluzole in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a riluzole savings card?

Yes. Save up to 90% on your riluzole with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a riluzole coupon provider in the US?

No. Now Patient does not provide riluzole coupons or FREE riluzole samples.

Do you accept commercial, Medicare or Medicaid coverage for riluzole in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much riluzole?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using riluzole. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much riluzole. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic riluzole?

US brand name of riluzole and manufacturer

Riluzole is available in the US under the brand names Rilutek, Tiglutik, and Exservan. It is manufactured by Sanofi-Aventis U.S. LLC.

UK brand name of riluzole and manufacturer

Riluzole is available in the UK under the brand name Rilutek. It is also manufactured by Sanofi-Aventis.

Is riluzole available in the UK on the NHS?

Yes, riluzole is available in the UK on the NHS as a prescription medication.

Prescription requirement for riluzole

Riluzole is a prescription medication and requires a prescription from a healthcare provider.

FDA approval of riluzole

Riluzole has received FDA approval for the treatment of amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig’s disease, and other motor neuron diseases.

Active ingredient of riluzole and mechanism of action

The active ingredient in riluzole is riluzole itself. Its precise mechanism of action in treating ALS is not fully understood, but it is believed to work by inhibiting the release of glutamate, a neurotransmitter that may contribute to the progression of ALS. By reducing the levels of glutamate, riluzole may help protect motor neurons from damage.

Uses of riluzole

Riluzole is a benzothiazole, primarily used for the treatment of amyotrophic lateral sclerosis (ALS). It is used to slow the progression of the disease and prolong survival in ALS patients. Riluzole is a presynaptic glutamate release inhibitor, which may delay muscle-strength deterioration and prevent neural damage.

Forms of riluzole

Riluzole is available in the form of oral tablets.

Dosage of riluzole

Riluzole therapy will depend on various factors, including the individual’s weight and the specific instructions provided by the healthcare provider. It is important to follow the dosage instructions carefully. Typically, the recommended starting dose is 50 mg taken orally twice daily, on an empty stomach.

Contraindications and warnings for riluzole

  • Riluzole may cause hepatic toxicity, and liver function tests should be conducted regularly during treatment
  • Inform your healthcare provider if you have liver disease or any other medical conditions
  • Riluzole may interact with other medications, so it is important to inform your healthcare provider about all the medications you are taking
  • If you experience any signs of liver problems, such as jaundice, dark urine, or persistent nausea, seek medical attention immediately
  • Riluzole may cause dizziness or drowsiness. Use caution when operating machinery or driving until you know how the medication affects you
  • It is not known if riluzole passes into breast milk. Speak to your doctor before breast-feeding

Side effects of riluzole

In clinical trials common side effects of riluzole may include:

  • Nausea
  • Abdominal pain
  • Loss of appetite
  • Fatigue
  • Weakness
  • Dizziness
  • Abnormal liver function tests

Get medical help right away if you have a serious allergic reaction. Symptoms include hives, trouble breathing, shortness of breath, chest pain, swelling of the face, tongue or throat (angioedema), skin rash, and severe skin reactions. Promptly report any adverse effects to a healthcare professional for medical advice.

Interactions with other drugs

Riluzole may interact with certain medications, including drugs that affect liver enzymes, and CYP1A2 inhibitors such as ciprofloxacin. It is important to inform your healthcare provider about all the prescription drugs, over the counter nonprescription medication, supplements, and vitamins you are taking to avoid potential drug interactions.


  • Rilutek Prescribing Information – Sanofi-Aventis U.S. LLC. 
  • Rilutek 50 mg film-coated tablets – electronic Medicines Compendium (eMC).
Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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