ribociclib/letrozole
Used for Cancer
NowPatient helps you obtain your ribociclib/letrozole prescription for free or at low-cost. Drug savings programs are suitable for individuals who are insured, don't have insurance or are underinsured and can't afford your medicine.
Manufactured by various FDA-approved generic manufacturers.
*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.
This content is intended for US audiences only
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ribociclib/letrozole key facts
What dosages is ribociclib/letrozole available in?
ribociclib/letrozole is copackaged containing:
- KISQALI: 200 mg
- FEMARA: 2.5 mg
What is ribociclib/letrozole used for?
ribociclib/letrozole, a co-packaged product containing ribociclib, a kinase inhibitor, and letrozole, an aromatase inhibitor, is indicated as initial endocrine-based therapy for the treatment of pre/perimenopausal or postmenopausal women with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic
breast cancer.
How does ribociclib/letrozole work?
ribociclib/letrozole contains two medications. Ribociclib works by slowing or stopping the growth of cancer cells. Letrozole works by decreasing the amount of estrogen the body makes, which helps slow down or reverse the growth of some breast cancers.
How do I take ribociclib/letrozole?
ribociclib/letrozole is dosed as follows:
ribociclib/letrozole contains both ribociclib and letrozole (an aromatase inhibitor) packaged together. It’s taken in a 1 month (28 days) cycle. For the first 3 weeks (21 days) of the cycle, the typical starting dose is 600 mg of ribociclib by mouth once daily. During the last week (7 days), you won’t take any ribociclib. At the end of the month, the cycle starts over again. During that last week when you aren’t taking ribociclib, you’ll still continue to use letrozole 2.5 mg by mouth daily.
Is it safe for me to take ribociclib/letrozole?
ribociclib/letrozole is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
ribociclib/letrozole Common Side Effects
Common side effects of ribociclib/letrozole:
- Neutropenia
- Nausea
- Infections
- Fatigue
- Leukopenia
- Diarrhea
- Hair loss
- Vomiting
- Headache
- Constipation
- Back pain
- Rash
- Anemia
ribociclib/letrozole Serious Side Effects
Serious side effects are rare with ribociclib/letrozole. Contact your healthcare provider immediately if you experience any of the following.
- Lung problems: cough, trouble breathing, shortness of breath, chest pain
- Severe skin reactions: severe rash or rash that keeps getting worse, reddened skin, flu-like symptoms, skin pain/burning, blistering of the lips, eyes or mouth,
blisters on the skin or skin peeling, with or without fever - Heart rhythm problems (QT prolongation): change in your heartbeat (a fast or irregular heartbeat), or if you feel dizzy or faint
- Liver problems: yellowing of your skin or the whites of your eyes (jaundice), dark or brown (tea-colored) urine, feeling very tired, loss of appetite, pain on the upper right side of your stomach area (abdomen)
- Low white blood cell counts (neutropenia): symptoms of infections such as fever and chills
Effects of other drugs, drug classes and over-the-counter products on ribociclib/letrozole
The following medications may interact with ribociclib/letrozole:
- CYP3A4 Inhibitors: Avoid concomitant use of KISQALI FEMARA COPACK with strong CYP3A inhibitors. If strong inhibitors cannot be avoided, reduce KISQALI dose
- CYP3A4 Inducers: Avoid concomitant use of KISQALI FEMARA COPACK with strong CYP3A inducers.
- CYP3A Substrates: The dose of sensitive CYP3A substrates with narrow therapeutic indices may need to be reduced when given concurrently with ribociclib/letrozole
- Drugs Known to Prolong QT Interval: Avoid concomitant use of drugs known to prolong QT interval, such as anti-arrhythmic medicines
Who makes ribociclib/letrozole?
Various FDA-approved generic manufacturers
Is ribociclib/letrozole safe in pregnancy?
ribociclib/letrozole can harm your unborn baby. If you are able to become pregnant, your healthcare provider should do a pregnancy test before you start treatment with ribociclib/letrozole. Females who are able to become pregnant and who take ribociclib/letrozole should use effective birth control during treatment and for at least 3 weeks after the last dose of ribociclib/letrozole. Talk to your healthcare provider about birth control methods that may be right for you during this time. If you become pregnant or think you are pregnant, tell your healthcare provider right away.
The FDA's medical product safety reporting program for health professionals, patients and consumers.
Learn more about reporting side effects in the USDrug Savings Guide
A practical guide to saving money and receiving support with prescription costs
How can NowPatient help me to lower the cost of my ribociclib/letrozole prescription?
After you create a FREE account with NowPatient, you will have access to 4 programs that can help lower the cost of your ribociclib/letrozole prescription
Applicability to each program will be dependent on your insurance status.
How do the NowPatient ribociclib/letrozole savings programs work?
After you have created your FREE account with NowPatient, you can access the various programs from your account dashboard. Each program has clear instructions on how to check your eligibility. You can see how the process works by clicking on the feature link below and seeing the ‘How it works’ steps.
Drug Coupon and Patient Assistance Programs require an eligibility quiz to be completed.
Are the NowPatient ribociclib/letrozole savings programs suitable for everyone, regardless of insurance status?
No. Each program has its own eligibility and applicability requirements. The table below shows if a program is available to you, based on your insurance status.
| Rx Advantage Card* for ribociclib/letrozole | Canadian Prescription Savings* for ribociclib/letrozole | ribociclib/letrozole Drug Coupon* | ribociclib/letrozole Patient Assistance Program* | |
| Insured (federal, state or government) | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured (Commercial or Private) | Available | Available | Available If Offered by Pharmaceutical Company | Available If Offered by Pharmaceutical Company |
| Uninsured | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
| Insured but without pharmacy benefit or drug coverage | Available | Available | Not Available | Available If Offered by Pharmaceutical Company |
*This is not insurance.
Are the NowPatient drug savings programs suitable for brand and generic versions of ribociclib/letrozole?
No. Each program has applicability requirements. Please see below
| Rx Advantage Card* for ribociclib/letrozole | Canadian Prescription Savings* for ribociclib/letrozole | ribociclib/letrozole Drug Coupon* | ribociclib/letrozole Patient Assistance Program* | |
| Brand | Yes | Yes | Yes, If Offered by Pharmaceutical Company | Yes, If Offered by Pharmaceutical Company |
| Generic | Yes | Yes | No | No |
*This is not insurance.
If you have Medicare Part D or Medicare Advantage and none of the ribociclib/letrozole savings options are applicable or affordable for me, what can you do?
If you are insured with Medicare and the ribociclib/letrozole drug savings options are not applicable to you and still remain unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and after you have selected your state, it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
People who qualify for both Medicare and Medicaid are called ‘dual eligibles’.
If you are denied Medicaid for ribociclib/letrozole, and you are still unable to afford your copay or co-insurance element (for example if you are in the coverage gap or Donut Hole) then you may be eligible for a federal support program like Low Income Subsidy. To be eligible for Low Income Subsidy, you need to be a resident in one of the 50 States or the District of Columbia. You can check eligibility online at SSA Medicare D Extra Help. You can also call Social Security at 1-800-772-1213 (TTY 1-800-325-0778).
I am uninsured or underinsured and none of the ribociclib/letrozole prescription saving options are applicable or affordable for me, what can I do?
If you are uninsured or underinsured (for example, ribociclib/letrozole is not covered by your plan) and the drug savings options are not applicable or still unaffordable, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. State Medicaid programs may cover the full cost of your medication.
If you are denied and all else fails, and if you have been prescribed ribociclib/letrozole for an FDA-approved indication, you can call the pharmaceutical company to see if they have any other assistance programs.
I am commercially or privately insured and none of the ribociclib/letrozole prescription saving options are applicable or affordable for me, what can I do?
If your medication is not covered by your plan, you can appeal your insurance company’s decision. Sometimes, a formal appeal can result in the drug being covered if it is deemed medically necessary.
If you cannot afford your copay contribution, then you can check Medicaid eligibility in your state by following the instructions at HealthCare.gov.
However, being privately insured might complicate your eligibility for Medicaid, as having private insurance may be considered in the financial eligibility assessment.
The government site is easy to use and you can select your state and it will navigate you to the appropriate contact point to make the application. If you qualify, state Medicaid may cover the full cost of your medication.
If I have federal, state or commercial insurance and none of the ribociclib/letrozole prescription saving options are applicable or affordable for me, are there any other support organisations that can help me with my co-insurance or copay contributions?
If you have already tried Medicaid and received a denial letter or if you are insured with Medicare and have been denied Low-Income Subsidy, then you can try one of the following organizational support programs:
1. Patient Access Network Foundation (PAN) assistance for ribociclib/letrozole
If you are having trouble paying for your ribociclib/letrozole medication due to unaffordable copays or deductibles, the Patient Access Network Foundation (PAN), may be able to assist you. To qualify for PAN assistance for ribociclib/letrozole you will need to meet one or all of the following criteria:
- Your income is below 400% of the federal poverty level
- ribociclib/letrozole is prescribed for an approved FDA indication
- You live in and receive treatment in the United States or U.S. territories, even if you do not have U.S. citizenship
- You have Medicare insurance coverage that covers ribociclib/letrozole
- If ribociclib/letrozole is listed on PAN’s list of covered medications
You can check the Patient Access Network Foundation Website for more information.
2. HealthWell Foundation Copay Program for ribociclib/letrozole
If you are having trouble paying for your ribociclib/letrozole medication due to unaffordable copays or deductibles, the HealthWell Foundation Copay Program may be able to assist you. To qualify for assistance for ribociclib/letrozole you will need to meet the following criteria:
- You live in and are being treated in the United States
- You are insured and your plan covers ribociclib/letrozole
- If ribociclib/letrozole is listed on the HealthWell Foundation’s list of covered medications
You can check the HealthWell Foundation Website for more information.
3. Patient Advocate Foundation Co-Pay Relief Program for ribociclib/letrozole
Patient Advocate Foundation’s Co-Pay Relief program exists to help reduce the financial distress you or your family may face when paying for your ribociclib/letrozole treatment. If you qualify and can demonstrate the need, the foundation will provide you with direct payment covering co-pays, co-insurance, and deductibles. To qualify for assistance for ribociclib/letrozole you will need to meet the following criteria:
- You must be currently insured and have coverage for ribociclib/letrozole
- You must have a confirmed diagnosis and treatment plan
- You must reside and receive treatment in the United States
- Your Income must fall at or below 300% or 400% of the Federal Poverty Guideline (FPG) with consideration for the Cost of Living Index (COLI) and number in the household
- Applications can also be completed by contacting the program sponsor, toll-free at 866-512-3861.
You can check the Patient Advocate Foundation Website for more information.
Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
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