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Rezenopy (naloxone hydrochloride) is a nasal spray used to treat opioid overdoses.

Rezenopy is available as a nasal spray that contains 10 mg of naloxone hydrochloride in 0.11 ml

Rezenopy is an opioid antagonist for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression in adult and pediatric patients.

Rezenopy works by blocking the effects of opiates on the brain and by restoring breathing. It will only work if a person has opiates in their system.

One spray of Rezenopy is given into one nostril in adult and pediatric patients. If the patient does not respond within 2 to 3 minutes or responds and then relapses into respiratory depression, an additional dose of may be given into the other nostril with a new device. You should not give more than 2 sprays of Rezenopy nasal spray per day.

Rezenopy is a safe and effective treatment when used for FDA approved indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not take this medication if you are allergic to naloxone hydrochloride.

Common side effects of Rezenopy: Upper stomach pain Common cold symptoms Altered or unpleasant taste

Serious side effects are rare with Rezenopy. Contact your healthcare provider immediately if you experience any of the following: Sudden opioid withdrawal symptoms: aggressive behavior, pain, fast heartbeat, sweating, irritability, vomiting

There are no drug interactions listed for Rezenopy.

Summit Biosciences Inc.

Available data from studies on naloxone use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage, or other adverse maternal or fetal outcomes. Life-sustaining therapy for opioid overdose should not be withheld.

• Naloxone Hydrochloride