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Rezdiffra (resmetirom) is an oral tablet used to treat liver disease caused by the build up of fat in the liver.

Rezdiffra is available as a 60 mg, 80 mg, and 100 mg oral tablet.

Rezdiffra is a thyroid hormone receptor-beta (THR-beta) agonist indicated in conjunction with diet and exercise for the treatment of adults with noncirrhotic nonalcoholic steatohepatitis (NASH) with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis).

Rezdiffra works by helping your body break down fat in the liver. This decreases inflammation and scarring.

Rezdiffra dosing is is based on actual body weight. Your dose may be decreased if you are taking a CYP2C8 inhibitor.

Rezdiffra is a safe and effective treatment when used for FDA approved indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Rezdiffra: Diarrhea Itching Nausea Vomiting

Serious side effects are rare with Rezdiffra. Contact your healthcare provider immediately if you experience any of the following: Allergic reactions: skin rash, itching, hives, swelling of the face, lips, tongue, or throat Gallbladder problems: severe stomach pain, nausea, vomiting, fever Liver injury: right upper belly pain, loss of appetite, nausea, light-colored stool, dark yellow or brown urine, yellowing skin or eyes, unusual weakness or fatigue.

The following medications may interact with Rezdiffra: Strong or Moderate CYP2C8 Inhibitors: Concomitant use not recommended (strong inhibitor [e.g., gemfibrozil]); or reduce Rezdiffra dosage (moderate inhibitor [e.g., clopidogrel]). OATP1B1 and OATP1B3 Inhibitors: Concomitant use with OATP inhibitors (e.g., cyclosporine) is not recommended. Atorvastatin, Pravastatin, Rosuvastatin and Simvastatin: Limit the daily dosage of the statin as recommended. â CYP2C8 Substrates: Monitor patients more frequently for substrate related adverse reactions.

Madrigal Pharmaceuticals, Inc.

It is not known whether Rezdiffra will harm your unborn baby. Talk with your healthcare provider about the risks of taking this medication if you are pregnant or plan on becoming pregnant.

• Resmetirom