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Reblozyl is the brand name for luspatercept-aamt and is available as a subcutaneous injection.

Reblozyl is available as a 25 mg or 75 mg subcutaneous injection.

Reblozyl is a biologic medication that is used to treat:
Anemia in adults with beta thalassemia who require regular red blood cell (RBC) transfusions Anemia in adults with myelodysplastic syndromes with ring sideroblasts (MDS-RS) or myelodysplastic/myeloproliferative neoplasms with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T) who can’t receive an erythropoiesis stimulating agent (ESA) and need regular RBC transfusion

Reblozyl is a biologic called an erythroid maturation agent. It helps immature red blood cells develop and work properly. By raising the amount of healthy red blood cells, it can treat your anemia.

You provider will determine your dose of Reblozyl based on your body weight. The typical starting dose is 1 mg/kg of body weight injected subcutaneously (under the skin) once every 3 weeks. Your provider will adjust your dose based on your response to the medication. Injections are given by your healthcare provider.

Reblozyl is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Reblozyl:

• Tiredness
• Headache
• Muscle or bone pain
• Joint pain
• Dizziness
• Nausea
• Diarrhea
• Cough
• Stomach pain
• Difficulty breathing
• Allergic reaction

Serious side effects are rare with Reblozyl. Contact your healthcare provider immediately if you experience any of the following.

• Blood clots: chest pain, trouble breathing, shortness of breath, pain in leg, cold or pale arm or leg, sudden numbness or weakness on one side of the body, severe headache or confusion, trouble speaking, difficulty walking, dizziness

There are no major drug interactions listed for Reblozyl. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Bristol-Myers Squibb

Reblozyl may harm your unborn baby. Tell your healthcare provider right away if you become pregnant or think you may be pregnant during treatment with Reblozyl.

Females who are able to become pregnant:

• Your healthcare provider should do a pregnancy test before you start treatment with Reblozyl
• You should use effective birth control (contraception) during treatment with Reblozyl and for at least 3 months after the last dose

• Luspatercept-AAMT