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Prilosec OTC is the brand name for omeprazole and is available as an oral tablet.

Prilosec OTC is available as a 20 mg oral tablet.

Prilosec OTC is a proton pump inhibitor that is used to treat heartburn.

Prilosec OTC is a proton pump inhibitor (PPI). It blocks acid from getting “pumped” into the stomach. This helps relieve heartburn and other medical conditions that cause too much stomach acid.

Prilosec OTC is typically taken as 20 mg by mouth once daily in the morning for 2 weeks.

Prilosec OTC is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known hypersensitivity to any component of the formulation or substituted benzimidazoles (angioedema and anaphylaxis have occurred)

Common side effects of Prilosec OTC:

• Headache
• Belly pain
• Nausea
• Diarrhea
• Vomiting
• Passing gas

Serious side effects are rare with Prilosec OTC. Contact your healthcare provider immediately if you experience any of the following.

• Severe stomach pain or diarrhea
• Kidney problems: urinating more or less than usual, fever, poor appetite, blood in urine
• Lupus symptoms: joint pain, skin rash on arms or cheeks that gets worse in the sunlight
• Serious allergic reaction: blistering, peeling, or bleeding skin; fever; chills; trouble breathing; face swelling

The following medications may interact with Prilosec OTC:

• Atazanavir and nelfinavir: Prilosec OTC reduces plasma levels of atazanavir and nelfinavir. Concomitant use is not recommended
• Saquinavir: Prilosec OTC increases plasma levels of saquinavir. Monitor for toxicity and consider dose reduction of saquinavir
• May interfere with drugs for which gastric pH affects bioavailability (e.g., ketoconazole, iron salts, ampicillin esters, and digoxin)
• Patients treated with Prilosec OTC and digoxin may need to be monitored for increases in digoxin toxicity.
• Co-administration of clopidogrel with 80 mg omeprazole may reduce the pharmacological activity of clopidogrel if given concomitantly or if given 12 hours apart.
• Cilostazol: Prilosec OTC increases systemic exposure of cilostazol and one of its active metabolites. Consider dose reduction of cilostazol
• Drugs metabolized by cytochrome P450 (e.g., diazepam, warfarin, phenytoin, cyclosporine, disulfiram, benzodiazepines): PRILOSEC can prolong their elimination. Monitor and determine need for dose adjustments
• Patients treated with proton pump inhibitors and warfarin may need to be monitored for increases in INR and prothrombin time
• Combined inhibitor of CYP 2C19 and 3A4 (e.g. voriconazole) may raise omeprazole levels
• Tacrolimus: Prilosec OTC may increase serum levels of tacrolimus
• Methotrexate: Prilosec OTC may increase serum levels of methotrexate

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It is not known if Prilosec OTC will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.

• Omeprazole