View PRILOSEC OTC savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or PRILOSEC OTC Patient Assistance Program.

Programs are suitable for individuals who want to buy PRILOSEC OTC without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by AstraZeneca

*Applicable to Drug Coupons & Patient Assistance Programs

This content is intended for US audiences only

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about PRILOSEC OTC



PRILOSEC OTC is the brand name for omeprazole and is available as an oral tablet.

What dosages is PRILOSEC OTC available in?

What dosages is PRILOSEC OTC available in?

PRILOSEC OTC is available as a 20 mg oral tablet.

What is PRILOSEC OTC used for?

What is PRILOSEC OTC used for?

PRILOSEC OTC is a proton pump inhibitor that is used to treat heartburn.

How does PRILOSEC OTC work?

How does PRILOSEC OTC work?

PRILOSEC OTC is a proton pump inhibitor (PPI). It blocks acid from getting “pumped” into the stomach. This helps relieve heartburn and other medical conditions that cause too much stomach acid.

How do I take PRILOSEC OTC?

How do I take PRILOSEC OTC?

PRILOSEC OTC is typically taken as 20 mg by mouth once daily in the morning for 2 weeks.

Is it safe for me to take PRILOSEC OTC?

Is it safe for me to take PRILOSEC OTC?

PRILOSEC OTC is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known hypersensitivity to any component of the formulation or substituted benzimidazoles (angioedema and anaphylaxis have occurred)

PRILOSEC OTC Common Side Effects

PRILOSEC OTC Common Side Effects

Common side effects of PRILOSEC OTC:

  • Headache
  • Belly pain
  • Nausea
  • Diarrhea
  • Vomiting
  • Passing gas
PRILOSEC OTC Serious Side Effects

PRILOSEC OTC Serious Side Effects

Serious side effects are rare with PRILOSEC OTC. Contact your healthcare provider immediately if you experience any of the following.

  • Severe stomach pain or diarrhea
  • Kidney problems: urinating more or less than usual, fever, poor appetite, blood in urine
  • Lupus symptoms: joint pain, skin rash on arms or cheeks that gets worse in the sunlight
  • Serious allergic reaction: blistering, peeling, or bleeding skin; fever; chills; trouble breathing; face swelling
Effects of other drugs, drug classes and over-the-counter products on PRILOSEC OTC

Effects of other drugs, drug classes and over-the-counter products on PRILOSEC OTC

The following medications may interact with PRILOSEC OTC:

  • Atazanavir and nelfinavir: PRILOSEC OTC reduces plasma levels of atazanavir and nelfinavir. Concomitant use is not recommended
  • Saquinavir: PRILOSEC OTC increases plasma levels of saquinavir. Monitor for toxicity and consider dose reduction of saquinavir
  • May interfere with drugs for which gastric pH affects bioavailability (e.g., ketoconazole, iron salts, ampicillin esters, and digoxin)
  • Patients treated with PRILOSEC OTC and digoxin may need to be monitored for increases in digoxin toxicity.
  • Co-administration of clopidogrel with 80 mg omeprazole may reduce the pharmacological activity of clopidogrel if given concomitantly or if given 12 hours apart.
  • Cilostazol: PRILOSEC OTC increases systemic exposure of cilostazol and one of its active metabolites. Consider dose reduction of cilostazol
  • Drugs metabolized by cytochrome P450 (e.g., diazepam, warfarin, phenytoin, cyclosporine, disulfiram, benzodiazepines): PRILOSEC can prolong their elimination. Monitor and determine need for dose adjustments
  • Patients treated with proton pump inhibitors and warfarin may need to be monitored for increases in INR and prothrombin time
  • Combined inhibitor of CYP 2C19 and 3A4 (e.g. voriconazole) may raise omeprazole levels
  • Tacrolimus: PRILOSEC OTC may increase serum levels of tacrolimus
  • Methotrexate: PRILOSEC OTC may increase serum levels of methotrexate



Is PRILOSEC OTC safe in pregnancy?

Is PRILOSEC OTC safe in pregnancy?

It is not known if PRILOSEC OTC will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.


What to do if you missed your PRILOSEC OTC dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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