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Pramipexole is available as a 0.125 mg, 0.25 mg, 0.5 mg, 0.75 mg, 1 mg, and 1.5 mg oral tablet.

Pramipexole is a dopamine agonist that is used to treat:
Parkinson’s disease moderate-to-severe restless legs syndrome

Pramipexole is a dopamine agonist. It’s not completely known how Pramipexole works. But it’s thought to raise dopamine levels in the brain to help improve movement problems for people with Parkinson’s disease or restless legs syndrome.

Pramipexole is typically started at 0.125 mg by mouth three times per day. If needed, your provider might raise your dose every 5 to 7 days to up to 1.5 mg three times per day.

Pramipexole is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Pramipexole:

• Sleepiness
• Nausea
• Constipation
• Dizziness
• Swelling in arms or legs
• Fatigue
• Hallucinations
• Dry mouth

Serious side effects are rare with Pramipexole. Contact your healthcare provider immediately if you experience any of the following.

• Neuroleptic malignant syndrome: fever, sweating, stiff muscles, confusion, not aware of your surroundings, fast or irregular heartbeat
• Severe muscle damage (rhabdomyolysis): dark brown urine, severe muscle weakness or pain, fever, tiredness
• Impulse-control behavior: intense urges for certain behaviors (e.g., gambling, shopping, binge eating, engaging in sexual activity)

The following medications may interact with Pramipexole:

• Dopamine antagonists: May diminish the effectiveness of Pramipexole

Various FDA-approved generic manufacturers

Pramipexole may cause harm to your unborn baby based on animal studies. You should talk to your healthcare provider before taking this medication if you are pregnant.

• Mirapex
• Mirapex ER