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Praluent is the brand name for alirocumab and is available as a subcutaneous injection.

Praluent is available as a 75 mg/mL or 150 mg/mL single-dose pre-filled pen.

Praluent is a PCSK9 inhibitor used for the following:

• Lower the risk of heart attack, stroke, and hospitalization for chest pain (angina) in adults with heart disease
• High cholesterol (including heterozygous familial hypercholesterolemia (HeFH)) in adults, alone or with diet and other cholesterol-lowering medications
• Homozygous familial hypercholesterolemia (HoFH) in adults, along with other cholesterol-lowering medications
• Heterozygous familial hypercholesterolemia (HeFH) in children ages 8 and older, along with diet and other cholesterol-lowering medications

Praluent is a proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitor, which means it blocks a protein called PCSK9. Normally, PCSK9 prevents the liver from removing LDL cholesterol from the blood. By blocking PCSK9, Praluent (alirocumab) helps your body clear out more LDL cholesterol, leading to lower cholesterol levels.

Praluent is typically dosed as follows:

Adults:

• High cholesterol or HeFH: The typical starting dose is 75 mg every 2 weeks or 300 mg every 4 weeks. If your LDL is still high, your prescriber might raise your dose to 150 mg every 2 weeks
• HeFH and undergoing LDL apheresis or HoFH: The typical dose is 150 mg every 2 weeks.

Children ages 8 and older with HeFH:

• Weigh less than 110 lbs (50 kg): The typical dose is 150 mg every 4 weeks. If your child’s LDL is still high, their prescriber might change the dose to 75 mg every 2 weeks.
• Weigh 110 lbs (50 kg) or more: The typical dose is 300 mg every 4 weeks. If your child’s LDL is still high, their prescriber might change the dose to 150 mg every 2 weeks.

Praluent is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication in the following:

• History of a serious hypersensitivity reaction to alirocumab or any of the excipients in the product

Common side effects of Praluent:

• Injection-site reactions
• Flu or flu-like symptoms
• Diarrhea

Serious side effects are rare with Praluent. Contact your healthcare provider immediately if you experience any of the following:

• Serious allergic reaction: swelling of the face, lips, tongue, or throat, trouble breathing, rash, hives, itching

There are no major drug interactions listed for this medication. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Sanofi-Aventis U.S.

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

• Alirocumab