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Polymyxin is available as an ophthalmic solution that contains Polymyxin B sulfate 10,000 units/ml and trimethoprim sulfate equivalent to 1 mg/ml.

Polymyxin is a combination of 2 antibiotics that is used to treat mild-to-moderate infections on the eye and eyelid.

Polymyxin is a combination of two antibiotics that work together to kill bacteria:

• Polymyxin B: is a polypeptide antibiotic that breaks the outer protective covering that bacteria need to grow and survive
• Trimethoprim is an antifolate. It works by stopping bacteria from being able to make a substance (folic acid) that’s needed for them to grow and survive

Polymyxin is typically taken as 1 drop in the affected eye(s) every 3 hours for 7 to 10 days. Don’t use more than 6 doses per day.

Polymyxin is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Polymyxin:

• Eye irritation (e.g., redness, burning, stinging, itching)
• Swollen eyelid(s)
• Red eyes
• Tearing

Serious side effects are rare with Polymyxin. Contact your healthcare provider immediately if you experience any of the following.

• Severe allergic reaction: hives; trouble breathing; swelling in the face, tongue, or throat

• There are no major drug interactions listed for Polymyxin. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking

Various FDA-approved generic manufacturers

It is not known if Polymyxin will harm your unborn baby. You should talk to your healthcare provider before taking this medication if you are pregnant.

• Polytrim