Used for Cancer

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Manufactured by Genentech, Inc.

*You can pay as little as $0 per fill using Drug Coupons or Patient Assistance Programs. Subject to applicability & eligibility requirements.

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PHESGO Uses, Side Effects, Interactions, Warnings & Dosing

What is PHESGO?

What is PHESGO?

PHESGO is the brand name for a subcutaneous injection that contains pertuzumab, trastuzumab, and hyaluronidase or hyaluronidase-zzxf.

What dosages is PHESGO available in?

What dosages is PHESGO available in?

PHESGO is available as a single dose vial containing one of the following:

  • 1,200 mg pertuzumab, 600 mg trastuzumab, and 30,000 units hyaluronidase/15 mL (80 mg, 40 mg, and 2,000 units/mL)
  • 600 mg pertuzumab, 600 mg trastuzumab, and 20,000 units hyaluronidase/10 mL (60 mg, 60 mg, and 2,000 units/mL)
What is PHESGO used for?

What is PHESGO used for?

PHESGO is a combination medication used to treat HER2-positive breast cancers, together with other chemotherapy.

How does PHESGO work?

How does PHESGO work?

PHESGO is a combination of three medications. Pertuzumab and trastuzumab are monoclonal antibodies that act as a human epidermal growth factor receptor 2 (HER2) inhibitor. It blocks a specific protein in the body that’s important for cell growth called HER2. HER2 is found on both normal and cancer cells. Cancer cells usually have more HER2 proteins than normal cells. This can cause cancer cells to grow more quickly than normal cells. When HER2 is blocked by PHESGO, cancer cells can’t grow and spread as well.
Hyaluronidase is a protein that helps your body absorb pertuzumab and trastuzumab better when injected under the skin.

How do I take PHESGO?

How do I take PHESGO?

PHESGO is given by a healthcare provider as an injection under the skin on the thigh. After the first dose, it’s given once every 3 weeks.

  • For the first dose, you’ll get 1,200 mg of pertuzumab, 600 mg of trastuzumab, and 30,000 units of hyaluronidase
  • For all other doses, you’ll get 600 mg of pertuzumab, 600 mg of trastuzumab, and 20,000 units of hyaluronidase
Is it safe for me to take PHESGO?

Is it safe for me to take PHESGO?

PHESGO is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you. You should not use this medication if you have a known hypersensitivity to
pertuzumab, or trastuzumab, or hyaluronidase, or to any of its excipients.

PHESGO Common Side Effects

PHESGO Common Side Effects

Common side effects of PHESGO:

  • Hair loss
  • Nausea
  • Diarrhea
  • Physical weakness
  • Tiredness
  • Mouth sores or inflammation
  • Joint or muscle pain
  • Constipation
  • Vomiting
PHESGO Serious Side Effects

PHESGO Serious Side Effects

Serious side effects are rare with PHESGO. Contact your healthcare provider immediately if you experience any of the following.

  • Heart problems: chest pain, racing heartbeat, shortness of breath that usually worsens with activity or while lying flat, swelling of your legs or feet, sudden weight gain, fatigue
  • Serious allergic reactions: trouble breathing, itching or hives, flushing, swelling, chest pain, fast heartbeat, dizziness
  • Lung problems: shortness of breath, trouble breathing
  • Serious infections (when receiving together with chemotherapy): repeated fevers, chills, sweating, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
Effects of other drugs, drug classes and over-the-counter products on PHESGO

Effects of other drugs, drug classes and over-the-counter products on PHESGO

The following medications may interact with PHESGO:

  • Patients who receive anthracycline after stopping PHESGO may be at increased risk of cardiac dysfunction because of PHESGO’s long washout period. If possible, avoid anthracycline-based therapy for up to 7 months after stopping PHESGO. If anthracyclines are used, carefully monitor the patient’s cardiac function
Who makes PHESGO?

Who makes PHESGO?

Genentech, Inc.

Is PHESGO safe in pregnancy?

Is PHESGO safe in pregnancy?

PHESGO can cause harm to your unborn baby when administered during pregnancy. You should take a pregnancy test prior to the initiation of PHESGO. Females of reproductive potential to use effective contraception during treatment and for
7 months following the last dose of PHESGO.


What to do if you missed your PHESGO dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

Learn more about reporting side effects
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NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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