PerphenazinePrices, Coupons & Savings

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*Based on the difference between the U&C price submitted and the price the patient paid, as of April 2023.

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  1. Medication
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  2. Perphenazine
    Generic for Trilafon
    30 tablets $8.1 USD
    Save $81.90
  3. Perphenazine
    Generic for Trilafon
    30 tablets $8.4 USD
    Save $81.60
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Do you need a prescription for perphenazine?

Yes, perphenazine is only available with a valid physician Rx.

How much is perphenazine without Insurance in the US?

Our website gives two competitive savings options to US customers who wish to purchase perphenazine, as either a brand or generic, if available. The first is access to medications through our mail-order online pharmacy. The second is by using the Now Patient Rx Advantage Card, which can be used in over 65,000 pharmacies nationwide, across America. If you are insured, then in most cases, the cash price will be significantly cheaper than the copay.

What will my out-of-pocket cost be for perphenazine in the US?

There are no out-of-pocket (OOP) costs because we are currently only offering a cash-based option to purchase medications.

Is Now Patient a perphenazine savings card?

Yes. Save up to 90% on your perphenazine with the FREE Now Patient Rx Advantage card*.
*Based on the difference between the U&C submitted by the pharmacy and the price the patients pay.

Can you handle Rx transfers for home delivery in the US?

Yes. If you use the mail-order online pharmacy option, then we can handle requests by you to have your prescription transferred to our pharmacy for home delivery. We can even help you manage your refills by giving you timely reminders, so you do not run out of your medication.

Is Now Patient a perphenazine coupon provider in the US?

No. Now Patient does not provide perphenazine coupons or FREE perphenazine samples.

Do you accept commercial, Medicare or Medicaid coverage for perphenazine in the US?

No. Currently, we only offer cash-based options for purchase, therefore we do not require your insurance benefit details. In the future, our plan is to be able to handle commercial insurance, Medicare and Medicaid including cases where you have multiple health plans that provide benefit coverage (e.g. Medicaid and Commercial). We also anticipate being able to handle more complex scenarios such as using primary insurance combined with a manufacturer copay assistance program.

Does Now Patient work with Medicare?

Our cash-based prices for medications are typically cheaper than Medicare copays. We do not bill Medicare Part D (standalone drug coverage) or Medicare Advantage (combined health and drug coverage). When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

Does Now Patient work with Commercial Insurance?

Our cash-based prices for medications are typically cheaper than commercial plan copays. We do not bill your commercial plan. When you purchase your medication from Now Patient, you will be doing so out of your pocket. The spend will not count towards your plan deductibles or gaps.

What should you do if you use too much perphenazine?


Call your doctor right away or seek immediate medical attention if your symptoms do not improve or they become worse after using perphenazine. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource if you think you’ve used too much perphenazine. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.


If you think it is an emergency, call 999 or find your nearest A&E
If you need help now, but it’s not an emergency go to 111.nhs.uk or call 111. Alternatively you can speak to one of our pharmacists or use the Now Patient app to make an appointment with your GP.

What should I do if I miss my dose?

There are occasions when people forget to take their medication at correct prescribed times. This may not only have an effect on potentially making the medication less effective but it may also inadvertently lead to taking doses too close together, thereby increasing the risks of side effects.

Click here to find out what to do if you forgot to take your medication

What is generic perphenazine?

Generic perphenazine refers to the non-brand-name version of the medication. It contains the same active ingredient as the brand-name drug but is typically less expensive.

FDA approval of perphenazine

Perphenazine is approved by the U.S. Food and Drug Administration (FDA) for the treatment of schizophrenia and other psychotic disorders.

Active ingredient of perphenazine

The active ingredient of perphenazine is perphenazine.

US brand name of perphenazine and manufacturer

Perphenazine is available in the US under various brand names, including Trilafon and Etrafon. It is manufactured by different pharmaceutical companies.

UK brand name of perphenazine and manufacturer

In the UK, perphenazine is available under the brand name Fentazin. The manufacturer may vary depending on the brand name.

Prescription requirement for perphenazine

A prescription (Rx) is required for perphenazine in both the US and the UK.

Availability of perphenazine in the UK with NHS prescription

Perphenazine is available in the UK with an NHS prescription.

Conditions treated by perphenazine

Perphenazine is primarily used for the treatment of schizophrenia and other psychotic disorders such as bipolar disorder. It helps to control the symptoms of psychosis, including hallucinations, delusions, and disorganized thinking.

How does perphenazine work?

The exact mechanism of action of perphenazine in the treatment of schizophrenia is not fully understood. It is believed to work by blocking the action of dopamine, a neurotransmitter that is involved in the regulation of mood and behavior. By reducing dopamine activity, perphenazine helps to alleviate the symptoms of psychosis.

Forms of perphenazine available

Perphenazine is available in the form of oral tablets and oral liquid concentrate.

Dosage of perphenazine

The dosage of perphenazine may vary depending on the individual’s condition, age, and response to the medication. It is important to follow the recommended dosage instructions provided by the healthcare provider.

Directions for perphenazine use

Perphenazine should be taken exactly as directed by the healthcare provider. The medication is usually taken orally, with or without food. It is important to take perphenazine consistently and continue the prescribed treatment course.

Warnings and precautions for perphenazine

  • Perphenazine may cause certain side effects, including drowsiness, dizziness, and movement disorders. It may also increase the risk of suicidal thoughts or behavior. Close monitoring is necessary during treatment
  • It may interact with certain medications, including other antipsychotic drugs and medications that affect heart rhythm. Inform the healthcare provider about all medications being taken
  • Tell your doctor if you are allergic to perphenazine, or other phenothiazines (such as chlorpromazine, or fluphenazine), before you start taking it
  • Speak to your doctor if you have ever had heart disease or high blood pressure, severe asthma, emphysema, Parkinson’s disease, breast cancer, adrenal gland tumor (pheochromocytoma), or urination problems

Use of perphenazine during pregnancy

The use of perphenazine during pregnancy should be carefully considered, and the potential risks and benefits should be discussed with a healthcare provider. The medication may be used during pregnancy if the potential benefits outweigh the risks.

Use of perphenazine while breastfeeding

Perphenazine may pass into breast milk. The use of perphenazine while breastfeeding should be discussed with a healthcare provider, considering the potential risks and benefits for the mother and the infant.

Possible side effects of perphenazine

Common side effects of perphenazine may include drowsiness, sedation, blurred vision, dry mouth, loss of appetite, constipation, and weight gain.
Serious side effects are possible but less common. Report any concerning adverse effects, such as tardive dyskinesia (uncontrolled movements of the mouth, tongue, jaw, arms, and/or legs), other extrapyramidal symptoms, and neuroleptic malignant syndrome (NMS).

Get emergency medical advice if you have an allergic reaction (hives, trouble breathing, swelling of your face, lips, tongue, or throat), muscle stiffness, severe tiredness, an irregular heartbeat, or dark urine.

Interactions with other drugs

Perphenazine may have an increased risk for drug interactions in patients taking other drugs. Some that may interact with perphenazine include antidepressants such as amitriptyline, antihistamines, barbiturates such as phenobarbital, haloperidol, medications for anxiety, motion sickness, Parkinson’s disease, sedatives, and certain selective serotonin reuptake inhibitors such as fluoxetine, paroxetine, and sertraline. It is important to inform your healthcare provider about all the medications you are taking including vitamins and herbal supplements, to avoid potential interactions.

Similar drugs to perphenazine

Other antipsychotic medications used for the treatment of schizophrenia and other psychotic disorders include haloperidol, risperidone, and olanzapine.


  • FDA Prescribing Information for Perphenazine
  • MHRA product information for Fentazin
  • WebMD – Perphenazine
  • Drugs.comPerphenazine
  • NHS UK


Now Patient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information in this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

Stefano Mirabello Medical Reviewer
Pharmacist / B.Pharm
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