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Pegvisomant is available as a 10 mg, 15 mg, 20 mg, 25 mg or 30 mg subcutaneous injection.

Pegvisomant is a growth hormone receptor antagonist that is used to treat acromegaly in people who either can’t get surgery or radiation, or for whom surgery or radiation didn’t work well.

Pegvisomant is a growth hormone receptor antagonist. It works by stopping growth hormone (GH) in your body from attaching to its receptors, which stops the hormone from working. This eases some symptoms of acromegaly, a condition that’s caused by having too much GH in the body.

Pegvisomant is dosed as follows:

• Starting dose: The typical starting dose is 40 mg injected under the skin on day 1, then 10 mg injected once per day starting on day 2
• Maintenance dose: The typical maintenance dose ranges from 10 mg to 30 mg injected under the skin once per day. Your provider might change your dose depending on the levels of a hormone called IGF-1 in your body. The maximum dose is 30 mg once per day

Pegvisomant is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Pegvisomant:

• Common cold, upper respiratory infection, or ear infection
• Pain
• Nausea
• Diarrhea
• Liver problems
• Flu-like symptoms
• Injection site reactions

Serious side effects are rare with Pegvisomant. Contact your healthcare provider immediately if you experience any of the following.

• Dangerously low blood sugar: feeling faint or dizzy; shaking; sweating; fast heartbeat; feeling nervousness, anxious, confused, irritable, or very hungry
• Liver problems: yellowing of your skin or the whites of your eyes, confusion, fatigue, low appetite, nausea, vomiting, stomach discomfort
• Severe allergic reaction: difficulty breathing; rash; swelling in your face, tongue, or lips

The following medications may interact with Pegvisomant:

• Insulin and/or Oral hypoglycemic Agents: Patients with acromegaly and with diabetes mellitus may require careful monitoring and dose reductions of insulin and/or oral hypoglycemic agents
• Opioids: Patients on opioids may need higher Pegvisomant doses to achieve appropriate IGF-1 suppression

Various FDA-approved generic manufacturers

It is not known if Pegvisomant will harm your unborn baby. Tell your healthcare provider if you become pregnant while using Pegvisomant.

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