pegvisomant
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Manufactured by various FDA-approved generic manufacturers.
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pegvisomant Uses, Side Effects, Interactions, Warnings & Dosing
What dosages is pegvisomant available in?
pegvisomant is available as a 10 mg, 15 mg, 20 mg, 25 mg or 30 mg subcutaneous injection.
What is pegvisomant used for?
pegvisomant is a growth hormone receptor antagonist that is used to treat acromegaly in people who either can’t get surgery or radiation, or for whom surgery or radiation didn’t work well.
How does pegvisomant work?
pegvisomant is a growth hormone receptor antagonist. It works by stopping growth hormone (GH) in your body from attaching to its receptors, which stops the hormone from working. This eases some symptoms of acromegaly, a condition that’s caused by having too much GH in the body.
How do I take pegvisomant?
pegvisomant is dosed as follows:
- Starting dose: The typical starting dose is 40 mg injected under the skin on day 1, then 10 mg injected once per day starting on day 2
- Maintenance dose: The typical maintenance dose ranges from 10 mg to 30 mg injected under the skin once per day. Your provider might change your dose depending on the levels of a hormone called IGF-1 in your body. The maximum dose is 30 mg once per day
Is it safe for me to take pegvisomant?
pegvisomant is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.
pegvisomant Common Side Effects
Common side effects of pegvisomant:
- Common cold, upper respiratory infection, or ear infection
- Pain
- Nausea
- Diarrhea
- Liver problems
- Flu-like symptoms
- Injection site reactions
pegvisomant Serious Side Effects
Serious side effects are rare with pegvisomant. Contact your healthcare provider immediately if you experience any of the following.
- Dangerously low blood sugar: feeling faint or dizzy; shaking; sweating; fast heartbeat; feeling nervousness, anxious, confused, irritable, or very hungry
- Liver problems: yellowing of your skin or the whites of your eyes, confusion, fatigue, low appetite, nausea, vomiting, stomach discomfort
- Severe allergic reaction: difficulty breathing; rash; swelling in your face, tongue, or lips
Effects of other drugs, drug classes and over-the-counter products on pegvisomant
The following medications may interact with pegvisomant:
- Insulin and/or Oral hypoglycemic Agents: Patients with acromegaly and with diabetes mellitus may require careful monitoring and dose reductions of insulin and/or oral hypoglycemic agents
- Opioids: Patients on opioids may need higher pegvisomant doses to achieve appropriate IGF-1 suppression
Who makes pegvisomant?
Various FDA-approved generic manufacturers
Is pegvisomant safe in pregnancy?
It is not known if pegvisomant will harm your unborn baby. Tell your healthcare provider if you become pregnant while using pegvisomant.
What to do if you missed your pegvisomant dose
The FDA's medical product safety reporting program for health professionals, patients and consumers.
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Medical Disclaimer
NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.
The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.
Things to know
What is the function of pegvisomant?
Does pegvisomant reduce tumor size?
What is the indication of pegvisomant?
How is pegvisomant administered?
What is the mechanism of action of pegvisomant?
Does pegvisomant decrease growth hormone?
How does pegvisomant affect GH levels?
What is the generic for pegvisomant?
What are the effects of pegvisomant treatment on growth hormone GH and insulin like growth factor 1 IGF-1 levels?
Is pegvisomant used for acromegaly?
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