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Pasireotide is available as an injectable suspension in strengths of 10 mg, 20 mg, 30 mg, 40 mg, and 60 mg.

Pasireotide is used to treat adults with acromegaly or Cushing’s disease for whom pituitary surgery is not an option or it did not work.

Pasireotide is a somatostatin analog. This means it acts just like somatostatin, a hormone made by your body that blocks the release of many other hormones to treat conditions like acromegaly or Cushing’s disease.

Pasireotide is typically dosed as follows:

• Acromegaly: The typical starting dose is 40 mg injected into the buttock muscle every 4 weeks. The maximum dose is 60 mg every 4 weeks.
• Cushing’s disease: The typical starting dose is 10 mg injected into the buttock muscle every 4 weeks. The maximum dose is 40 mg every 4 weeks.

Pasireotide is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

Common side effects of Pasireotide:

• Diarrhea
• Nausea
• High blood sugar
• Gallstones
• Stomach pain

Serious side effects are rare with Pasireotide. Contact your healthcare provider immediately if you experience any of the following:

• Dangerously low blood sugar: feeling faint, shaking, sweating, dizziness, fast heartbeat, nervousness, anxious, confused, irritable, feeling very hungry
• Dangerously high blood sugar: frequently thirsty, needing to urinate often, tiredness, nausea, vomiting, difficulty breathing, having fruity breath, having dry mouth
• Extremely low cortisol level: weight loss, feeling very weak, feeling tired, vomiting, no appetite
• Heart rhythm problems: Chest pounding, fluttering in the chest, difficulty breathing, chest pain, feeling faint or lightheaded
• Swelling of the gallbladder or pancreas: sudden pain in upper right portion of your stomach area, back pain between your shoulder blades, nausea, vomiting, fever, swelling in the belly, fast heartbeat, difficulty breathingDangerously low blood sugar: feeling faint, shaking, sweating, dizziness, fast heartbeat, nervousness, anxious, confused, irritable, feeling very hungry
• Dangerously high blood sugar: frequently thirsty, needing to urinate often, tiredness, nausea, vomiting, difficulty breathing, having fruity breath, having dry mouth
• Extremely low cortisol level: weight loss, feeling very weak, feeling tired, vomiting, no appetite
• Heart rhythm problems: Chest pounding, fluttering in the chest, difficulty breathing, chest pain, feeling faint or lightheaded
• Swelling of the gallbladder or pancreas: sudden pain in upper right portion of your stomach area, back pain between your shoulder blades, nausea, vomiting, fever, swelling in the belly, fast heartbeat, difficulty breathing

The following medications may interact with Pasireotide:

• Drugs that prolong QT
• Cyclosporine
• Bromocriptin

Various FDA-approved generic manufacturers

It is not known whether this medication is safe for you and your unborn baby during pregnancy. Talk to your doctor if you are already pregnant or if you have plans on becoming pregnant. They will recommend what is best for you.

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