Used for Cancer

View OPDUALAG savings options available to you including Manufacturer Coupons, Rx Advantage Savings Card, Canadian Prescription Savings or OPDUALAG Patient Assistance Program.

Programs are suitable for individuals who want to buy OPDUALAG without insurance, with insurance or for those who are underinsured. You can pay as little as $0 per fill.*

Manufactured by Bristol-Myers Squibb

*Applicable to Drug Coupons & Patient Assistance Programs

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Jamie Winn NowPatientGreen tick
Updated on 26 Apr 2024

Learn more about OPDUALAG



OPDUALAG is the brand name for nivolumab and relatlimab-rmbw and is available as an IV infusion.

What dosages is OPDUALAG available in?

What dosages is OPDUALAG available in?

OPDUALAG is available as 240 mg of nivolumab and 80 mg of relatlimab per 20 mL (12 mg and 4 mg per mL) in a single-dose vial.

What is OPDUALAG used for?

What is OPDUALAG used for?

OPDUALAG is a PD-1 and LAG-3 inhibitor that is used to treat melanoma skin cancer that has spread or can’t be removed by surgery (people ages 12 years and older).

How does OPDUALAG work?

How does OPDUALAG work?

OPDUALAG is a combination medication that blocks both the PD-1 (nivolumab) and LAG3 (relatlimab) pathways. When these pathways are blocked, the immune system is activated to attack cancer cells. As a result, the immune system can kill cancer cells and stop cancer cells from growing.

How do I take OPDUALAG?

How do I take OPDUALAG?

OPDUALAG is dosed as follows:

People ages 12 years and older (who weigh at least 40 kg):

  • The typical dose of OPDUALAG is 480 mg of nivolumab and 160 mg of relatlimab every 4 weeks. It’s given as an intravenous (IV) infusion that includes both medications given at the same time.
Is it safe for me to take OPDUALAG?

Is it safe for me to take OPDUALAG?

OPDUALAG is a safe and effective treatment when used for FDA licensed indications. However, like all medications, they may give you unwanted side effects. You should always discuss potential side effects with your physician to ensure the medication is suitable and right for you.

OPDUALAG Common Side Effects

OPDUALAG Common Side Effects

Common side effects of OPDUALAG:

  • Muscle pain
  • Tiredness
  • Lower red blood cell count
  • Lower white blood cell count
  • Higher liver enzymes in blood
  • Rash
  • Itching
  • Diarrhea
  • Lower sodium level in blood
OPDUALAG Serious Side Effects

OPDUALAG Serious Side Effects

Serious side effects are rare with OPDUALAG. Contact your healthcare provider immediately if you experience any of the following.

  • Serious immune-related side effects: rash, diarrhea, trouble breathing, severe stomach pain, chest pain
  • Serious reaction during infusion: itching, trouble breathing, fast heart beat, feeling warm or hot
Effects of other drugs, drug classes and over-the-counter products on OPDUALAG

Effects of other drugs, drug classes and over-the-counter products on OPDUALAG

There are no major drug interactions listed for OPDUALAG. However, always let your physician and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking.

Who makes OPDUALAG?

Who makes OPDUALAG?

Bristol-Myers Squibb

Is OPDUALAG safe in pregnancy?

Is OPDUALAG safe in pregnancy?

OPDUALAG can harm your unborn baby. Females who are able to become pregnant: Your healthcare provider should do a pregnancy test before you start receiving OPDUALAG. You should use an effective method of birth control during and for at least 5 months after the last dose of OPDUALAG. Talk to your healthcare provider about birth control methods that you can use during this time. Tell your healthcare provider right away if you become pregnant during treatment with OPDUALAG.


What to do if you missed your OPDUALAG dose

The FDA's medical product safety reporting program for health professionals, patients and consumers.

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Medical Disclaimer

NowPatient has taken all reasonable steps to ensure that all material is factually accurate, complete, and current. However, the knowledge and experience of a qualified healthcare professional should always be sought after instead of using the information on this page. Before taking any drug, you should always speak to your doctor or another qualified healthcare provider.

The information provided here about medications is subject to change and is not meant to include all uses, precautions, warnings, directions, drug interactions, allergic reactions, or negative effects. The absence of warnings or other information for a particular medication does not imply that the medication or medication combination is appropriate for all patients or for all possible purposes.

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